A Cleveland Clinic research trial was the first in the United States to offer uterus transplant to women suffering from uterine factor infertility (UFI). These women cannot carry a pregnancy. They were born without a uterus or have lost their uterus. Since Cleveland Clinic began the clinical trial, the team has completed eight uterus transplants; six transplants were successful, including two births and two resulted in hysterectomies. Currently, women are awaiting embryo transfers, while candidates are listed for transplant.

  • 2020: Cleveland Clinic Delivers 2nd Baby from Deceased-Donor Uterine Transplant. Cleveland Clinic transplants one uterus.
  • 2019: First in North America to Deliver Baby from Deceased-Donor Uterine Transplant. Cleveland Clinic transplants five uteri. Cleveland Clinic second embryo transfer which resulted in pregnancy.
  • 2018: Cleveland Clinic first embryo transfer which resulted in pregnancy.
  • 2017: Cleveland Clinic second uterus transplant.
  • 2016: Cleveland Clinic’s multidisciplinary surgical team performs the nation’s first uterus transplant on Feb 24, 2016. Learn More
    Cleveland Clinic announced the removal of the transplanted uterus due to a candida infection on March 9, 2016. Learn More

How it Works

Uterus transplantation is a major feat of microsurgical engineering. Here's how it's done.

Path to Parenthood

Candidates get in-depth screening

Must be 21-39 with
uterine factor infertility (UFI)

Evaluated by team of experts

IVF starts

Patient’s ovaries stimulated

Eggs retrieved & fertilized in lab

6 embryo's frozen

Deceased donor

18-40 with a healthy uterus

Next of kin must consent

Prep and transplant

Anti-rejection drugs started

Donor uterus transplanted into patient’s pelvis

IVF continues

In a few months, periods begin

Minimum 6 months after transplant, uterus heals

Embryos implanted one by one

Goal: 1-2 live births

Pregnancy monitored

Anti-rejection drugs and labs required throughout

Monthly biopsies check for rejection


Baby delivered by C-section

Donor uterus removed after 1-2 live births

Anti-rejection drugs stop

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