A Cleveland Clinic research trial was the first in the United States to offer uterus transplant to women suffering from uterine factor infertility (UFI). These women cannot carry a pregnancy. They were born without a uterus or have lost their uterus. Since Cleveland Clinic began the clinical trial, the team has completed five uterus transplants; three transplants were successful, including one birth and two resulted in hysterectomies. Currently, women are awaiting embryo transfers, while several more candidates are listed for transplant.
Uterus transplantation is a major feat of microsurgical engineering. Here's how it's done.
Candidates get in-depth screening
Must be 21-39 with
uterine factor infertility (UFI)
Evaluated by team of experts
Patient’s ovaries stimulated
Eggs retrieved & fertilized in lab
6 embryo's frozen
18-40 with a healthy uterus
Next of kin must consent
Prep and transplant
Anti-rejection drugs started
Donor uterus transplanted into patient’s pelvis
In a few months, periods begin
Minimum 6 months after transplant, uterus heals
Embryos implanted one by one
Goal: 1-2 live births
Anti-rejection drugs and labs required throughout
Monthly biopsies check for rejection
Baby delivered by C-section
Donor uterus removed after 1-2 live births
Anti-rejection drugs stop
A quick collage of the faces, hands and teams that made the delivery possible.