A Cleveland Clinic research trial was the first in the United States to offer uterus transplant to women suffering from uterine factor infertility (UFI). These women cannot carry a pregnancy. They were born without a uterus or have lost their uterus. Since Cleveland Clinic began the clinical trial, the team has completed eight uterus transplants; six transplants were technically successful, with four livebirths thus far. Currently, two women are awaiting embryo transfers, while other candidates are listed for transplant.

Cleveland Clinic’s clinical trial milestones:

  • Became the first in North America to deliver a baby from a deceased-donor uterine transplant in 2019.
  • Performed their first embryo transfer in a uterus recipient, resulting in pregnancy in 2018.
  • Performed the nation’s first uterus transplant on Feb. 24, 2016, which was removed on March 9, 2016 due to a candida infection.

How it Works

Uterus transplantation is a major feat of microsurgical engineering. Here's how it's done.

Path to Parenthood

Candidates get in-depth screening

Must be 21-39 with
uterine factor infertility (UFI)

Evaluated by team of experts

IVF starts

Patient’s ovaries stimulated

Eggs retrieved & fertilized in lab

6 embryo's frozen

Deceased donor

18-40 with a healthy uterus

Next of kin must consent

Prep and transplant

Anti-rejection drugs started

Donor uterus transplanted into patient’s pelvis

IVF continues

In a few months, periods begin

Minimum 6 months after transplant, uterus heals

Embryos implanted one by one

Goal: 1-2 live births

Pregnancy monitored

Anti-rejection drugs and labs required throughout

Monthly biopsies check for rejection


Baby delivered by C-section

Donor uterus removed after 1-2 live births

Anti-rejection drugs stop

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