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Cleveland Clinic - Ranked One of America's Top Hospitals

Program Director


Dr. Ashok Agarwal

Professor, Lerner College of Medicine,
Case Western Reserve University
Director, Andrology Center
Director, American Center for Reproductive Medicine
Staff, Glickman Urological & Kidney Institute, and
Ob-Gyn and Women's Health Institute,
Anatomic Pathology, and Immunology
Cleveland Clinic
10681 Carnegie Ave., X11
Cleveland, Ohio 44195 USA
Tel: 216-444-9485; Fax: 216-445-6049
ResearchGate Profile
LinkedIn Profile
Wikipedia Profile
Dr. Agarwal's Twitter: @AshokAgarwalCCF
ACRM's Twitter: @CleClinReproMed
ACRM's Facebook: Cleveland Clinic Center for Reproductive Medicine

About Us


The American Center for Reproductive Medicine is a research program of the Cleveland Clinic Glickman Urological & Kidney Institute (rated as No. 1 in the country by the US News and World Report). Our Center is rated as a leading center of excellence at the world-class Cleveland Clinic, which is recognized by U.S. News & World Report as one of the nation's best hospitals, ranked as No. 2 in the country. Over the past 25 years our Center has trained over 1,000 pre-med/ medical students, physicians, scientists and biologists from more than 50 countries.

Center's summer internship offers a unique opportunity for students interested in gaining a research experience in human fertility and reproductive biology and the opportunity of working with world-renowned scientists and researchers. Members of our staff publish frequently in most respected journals, are invited guest speakers at important scientific/ medical meetings and courses around the world and are active in the leading professional societies in the exciting field of human reproductive medicine. For an up to date list of our publications, kindly visit A Scopus Citation Report of Research Publications by the American Center for Reproductive Medicine from 1993 to 2017 is available here.

Program Goals and Benefits


Summer Intership Covers

The American Center for Reproductive Medicine at Cleveland Clinic offers a unique and exciting summer internship opportunity for highly motivated, academically oriented medical or undergraduate students interested in a career in medicine.

The center provides an excellent environment to learn the art of scientific writing in medicine. This unsurpassed experience gives participants the opportunity to:

  • Immerse themselves in a state-of-the-art research environment
  • Be mentored by renowned researchers at a world-class medical institution
  • Develop a strong foundation for pursuing a career in academic medicine

The program's goal is to encourage students to consider a career in medicine, whether in reproductive medicine or any other specialty of their choosing. To this end, we have designed an exceptional summer internship program to provide students a wide range of experiences.

During this 5-week program, participants will:

  • Work alongside reproductive scientists and clinicians in learning about basic laboratory techniques in a real laboratory environment.
    Some of the laboratory techniques learned by the Summer Interns of 2017 included:
    1. Measuring sperm concentration and motility in semen samples for semen analysis
    2. Confirmation of leukocytospermia for cases of infection
    3. Evaluation of sperm vitality by eosin-nigrosin and hypoosmotic swelling test to check for sperm membrane integrity
    4. Evaluation of sperm morphology according to World Health Organization 5th edition guidelines
    5. Sperm preparation techniques for intrauterine insemination
    6. Sperm cryopreservation for long term storage of semen samples for fertility preservation
    7. Demonstration of sperm DNA fragmentation by TUNEL assay
  • Interact with reproductive endocrinologists, gynecologists, male infertility specialists and urologists.
  • Participate in daily didactics, research meetings, and group discussions.

Students will develop a strong understanding of how reproductive research is conducted. Participants will also learn how to:

  • Record laboratory results and conduct preliminary statistical analysis
  • Present results of laboratory training in departmental meetings
  • Prepare and present PowerPoint talks
  • Hone their public speaking skills

Some of the writing projects offered to the 2017 Summer Interns include:

  1. Role of Antioxidants in Male Infertility and Antioxidant Overuse
  2. The Role of Reactive Oxygen Species on DNA Damage and Male Infertility
  3. Anti-infection and Anti-inflammation ROS treatment of Prostatitis in Male Infertility
  4. Physiological Role of Reactive Oxygen Species in Sperm Maturation
  5. Causes of Oxidative Stress in Male Infertility

Summer Intern Authors

The articles from the 2014 class were selected for publication in the following book.
Proteomics in Human Reproduction (Ashok Agarwal, Luna Samanta, Ricardo P. Bertolla, Damayanthi Durairajanayagam, Paula Intasqui) ISBN: 978-3-319-48418-1 (Print)
Summer Intern Author: Carolina Cirenza
This Brief explores the use of proteomics as a tool for biomarker discovery in human reproduction and summarizes current findings and trends of proteomic studies in both male and female infertility. This simplifies this important but complex topic and equips the novice reader with sufficient background information on the use of proteomics in human reproduction. The up-to-date scenario on proteomic investigations will also appeal to researchers and post-graduate students looking to keep abreast with the latest developments in reproductive research.

Oxidative Stress in Human Reproduction - Shedding Light on a Complicated Phenomenon (Ashok Agarwal, Rakesh Sharma, Sajal Gupta, Avi Harlev, Gulfam Ahmad, Stefan S du Plessis, Sandro C. Esteves, Siew May Wang, Damayanthi Durairajanayagam) ISBN: 978-3-319-48425-9 (Print)
Summer Intern Authors: Mohamed Iesar Abdelaziz, Muna M. Abuayyash, Ghada Al Hayaza, Luay AlKattan, Saad AlQasem, Rakan Alsaad, Fares Bamajbour, Eiad Habib, Zeina Kayali, Deepak Kumar, Mohammad Nouth, Yash Sarda, Amolak S. Dhillon, Nirvika Singh, My Tran
This book discusses the role of oxidative stress in the reproductive system. The book reviews endogenous sources, methods of determining its levels in body fluid/tissues, the physiological roles of ROS, as well as its negative effects on the human reproductive processes. Also discussed are multiple extrinsic factors that could induce oxidative stress in the reproductive system.
Hot off the Press: Latest High Impact Publication(s) by Intern(s)!
Cumene Hydroperoxide Induced Changes in Oxidation-Reduction Potential in Fresh and Frozen Seminal Ejaculates. (Original Article).
Dr. Ashok Agarwal, Dr. Rakesh Sharma, Dr. Ralf Henkel, Dr. Suresh Sikka, Dr. Stefan du plessis, Sarda B Yash, Carolina Speyer, Nouh Muhammed, Christopher Douglas, Zeina Kayali, Ahmed Elshaer, Dr. Edmund Sabanegh.
Published in Andrologia (Impact Factor = 1.458), Date Published: 15 March, 2017.
Summer Intern Authors: Yash Sarda, Carolina Speyer, Mohammad Nouh, Christopher Douglas, Zeina Kayali

Ascorbic Acid Reduces Redox Potential in Human Spermatozoa Subjected to Heat-Induced Oxidative Stress. (Original Article).
Dr. Ahmed Gulfam, Dr. Ashok Agarwal, Dr. Sandro C Esteves, Dr. Rakesh Sharma, Mazen Almasry, Ali Al-Gonaim, Ghada AlHayaza, Nirvika Singh, Luay Al Kattan, Wassel M Sannaa, Dr. Edmund Sabanegh
Published in Andrologia (Impact Factor = 1.458), Date Published: March 1 2017.
Summer Intern Authors: Mazen Almasry, Ali Al-Gonaim, Nirvika Singh, Luay Al Kattan, Wassel Sannaa

Abstinence Time and Its Impact on Basic and Advanced Semen Parameters.
Dr. Ashok Agarwal, Dr. Sajal Gupta, Dr. Stefan du plessis, Dr. Rakesh Sharma, Dr. Sandro C Esteves, Caroline Cirenza, Jasmine Eliwa, Wedad Al-Najjar, Deepika Kumaresan, Namariq Haroun, Sara Philby, Dr. Edmund Sabanegh
Published in Urology (Impact Factor = 2.309), Date Aug 2016.
Summer Intern Authors: Carolina Cirenza, Jasmine Eliwa, Wedad Al-Najjar, Deepika Kumaresan, Namariq Haroun, Sara Philby

Browse Research Publications by Interns

2016 Interns'
2015 Interns'
2014 Interns'
2013 Interns'
2012 Interns'
2011 Interns'
2010 Interns'
2009 Interns'
2008 Interns'

Additional Benefits of Internship


A unique aspect of this internship is the emphasis placed by the program on cultivating soft skills and imbibing professionalism in all participants. Skills honed during the internship include:

  • leadership
  • volunteerism
  • time management
  • effective communication
  • public speaking and presentation skills

These skills and abilities are highly valued and have a prolonged impact on participants, especially as they pursue their goals and develop careers.

The intangible mix of skills nurtured during our internship sets our interns distinctly apart from their peers and empowers them to:

  • be highly competitive in their interviews for medical school, residency or jobs
  • perform better at public speaking opportunities
  • be stronger candidates when being considered for work positions

Among the 25 fundamental values weaved through the internship syllabus are:

The teaching-learning modalities used to impart these values include:

  • 1. Mentorship
  • 2. Role modeling
  • 3. Demonstrations
  • 4. Small-group sessions
  • 5. One-on-one discussions
  • 6. Individualized coaching


Summer Internship


Who can apply?

Apply Online Q&A

Undergraduate students, medical students, residents, and recent graduates.

Both local (US nationals) and foreign (international) applicants are welcome to apply.

How to apply:

Our selection procedure for summer internship positions is highly competitive. Twenty One students were selected to participate in our program in the summer of 2016. Interested applicants should submit the following:

  • Recent curriculum vitae/resume
  • At least two recent letters of recommendation from advisors, teachers, or persons who have a firsthand knowledge of the candidate. The following is not acceptable: LORs sent as an e-mail and not printed on official letterhead, not carrying a signature, letters written more than 6-8 weeks before the date of submission. What is acceptable: LORs submitted via e-mail as scanned files either directly by the referee or a candidate. Please see the application page for further guidelines.
  • Address and telephone number for a personal interview
  • A 500-word personal statement
  • Proof of medical insurance
  • A letter stating that the participant has the necessary funding to support him/herself for the 4-week program (the internship is not funded and no financial support is available). This letter could be written by the candidate.
  • An application processing fee of USD $150.00 in the form of a money order or certified bank check only - payable to "2018 Internship in Reproductive Medicine". This fee is non-refundable.
  • A non-refundable course fee of USD $4,500.00 will be required from candidates accepted for the internship. This fee may be submitted as a money order or certified bank check (no personal checks) made payable to "2018 Internship in Reproductive Medicine". Overseas candidates should review the course fee by clicking here.

Where to submit:

Program Director
American Center for Reproductive Medicine
Cleveland Clinic
10681 Carnegie Avenue, X11
Cleveland, OH 44195 USA
Tel: (216) 444-9485; Fax: (216) 445-6049

Application Deadline: March 03, 2017

Internship Dates: June 12, 2017 to July 28, 2017

Other Important Information:

  • Foreign students and graduates are welcome to apply.
  • Research work conducted during the internship may qualify for undergraduate course credit(s). Interested participants should check with their academic advisers.
  • Successful completion of internship results in the award of a Certificate of Research Training from the American Center for Reproductive Medicine.

Expectations and Grading Criteria



1. Expectations

  • a) Expectations by CRM Mentors for Incoming Interns
    As an Intern accepted into the CRM Internship Program, incoming interns are expected tofulfill their job description to maximize the benefits that they will obtain from the program. Read more about this here.
  • b) Adherence to Policy and Procedures
    Incoming interns are expected to abide by the policy and procedures of the Center forReproductive Medicine and Cleveland Clinic. Read more about this here.
  • c) Incoming Interns can Expect Internship Mentors to
    Incoming interns can expect their Mentors to provide them with valuable Mentorship throughout the program. Read more about this here.

    Click image for larger view

2. Method to Evaluate Scientific Writing
Interns are expected to fulfill the learning objectives associated with Scientific writing in order successfully participate in the Summer Internship. Read more about the criteria that will be evaluated here.

3. Method to Evaluate Laboratory Training
Interns are expected to understand basic principles and be able to conduct basic laboratory tests to successfully participate in the Internship Program. Read more about the criteria that will be evaluated here.

4. Grading of Interns
Interns will be expected to fulfill the learning objectives of the Internship Program in order to achieve successful participation in the Internship Program. Read more about the criteria that will be evaluated here.

5. Criteria for Award of Graduation Certificate
In order to be awarded the Internship Graduation Certificate, interns should score the equivalent of a pass, pass with honors or pass with distinction. Read more about the criteria that will be evaluated here.

Facilities & Resources


The Laboratories
Research and Clinical Laboratories occupy over 5000 square feet of workspace with state-of-the-art instruments and facilities for advanced research in fertility preservation in patients with cancer, proteomics of male and female infertility and molecular markers of oxidative stress and DNA integrity.

Equipment and Instrumentation
Instruments available in our facility include: computer assisted semen analyzers, luminometer for oxidative stress measurements, Accuri BD C6 flow cytometer, equipment for western blot, culture room equipped with a sterile hood, several incubators, microscopes, and Narishige micromanipulator fitted on an inverted phase-contrast microscope, spectrophotometers, ELISA plate reader, centrifuges, liquid nitrogen storage tanks, programmable freezers, cold room, etc.

Core Laboratories
The laboratory has ready access to over a dozen highly-specialized core laboratories within the Cleveland Clinic Lerner Research Institute. These include: proteomics, metabolomics, genomics, molecular biotechnology, molecular screening, flow cytometry, mass spectrometry, translational research, digital imaging and electron microscopy, etc. For more information on these core laboratories, please visit:

IT Equipment
Along with office supplies, the office space for Fellows is equipped with over 2 dozen computers with laser printers, scanners, copiers, and all the necessary software programs. All computers in the Center are connected to the Cleveland Clinic's intranet that provides direct access to most online journals related to the field of medicine, urology, reproductive medicine, andrology, oby-gyn, etc.

A large collection of scientific journals, electronic journals/books, and other databases are available through the resourceful Cleveland Clinic Alumni Library. Specialized Medical Librarians are ever willing to help in research and use of electronic databases. Statistical research support is readily available from a team of biostatisticians working in the Department of Quantitative Health Sciences (QHS). Services for the design and creation of medical illustration for publication purposes are provided by The Center for Medical Art and Photography (CMAP) Arts and Photo also aid in the preparation of research posters and lecture slides for presentations at national meetings.



Andrology Lab Booklet

Graduating Interns (2017)


Hashem Albunni

Alfaisal University
Kingdom of Saudi Arabia


Albert Bui

Ohio University Heritage College of Osteopathic Medicine
Athens, OH


Emily Qui

University of California
Berkeley Berkeley, CA


Mohit Rana

Cleveland State University
Cleveland, OH


Inderpreet Sandhu Singh

Government Medical College
Amritsar, India


Invited Faculty 2017

Avraham Harlev

Senior Physician in the Fertility and IVF Unit, Soroka University Medical Center, Israel.


Charles Dorsey

Director of Commercial Innovation at Aytu BioScience, Inc.


Sijo Parekattil

Co-Director Personalized Urology & Robotics Clinic South Lake Hospital & Orlando Health Clermont, Florida


Organizing Faculty 2017

Ashok Agarwal

Professor, Cleveland Clinic Lerner College of Medicine, Director, Andrology Center, Director, American Center for Reproductive Medicine and Director, 2016 Summer Internship Program


Rakesh Sharma

Associate Professor, Cleveland Clinic Lerner College of Medicine, Research Coordinator, American Center for Reproductive Medicine, Coordinator, Andrology Center


Sajal Gupta

Assistant Professor, Cleveland Clinic Lerner College of Medicine, Assistant Research Coordinator, American Center for Reproductive Medicine, Supervisor, Andrology Center


Manesh Kumar Panner Selvam

Research Fellow at the American Center for Reproductive Medicine


Ralf Henkel, Ph.D

Visiting Faculty and Summer Internship Coordinator at the American Center for Reproductive Medicine




Scientific Presentations (2017)

Presentations 2016

The summer interns gave a 15 minute presentation regarding their Scientific Writing Topic on the final day of presentation day of the 2017 Summer Internship program held on Friday, July 28th, 2017. The presentation were held from 8:30am to 12:30 pm. The audience comprised of leader in the field of reproductive medicine, faculty, parents, fellows, and interns.

Scientific Program

Internship Awards


Reception Dinner

Dinner 2016

The reception dinner started from 6:00 PM onwards and included an awards ceremony and a gala dinner.


2017 Group Photos
2017 Summer Internship
2017 Laboratory Shoot
Scientific Presentations and Guest Lectures
Awards Ceremony

Student Feedback (2013 Interns)

Click on the pictures below to hear what our former interns have to say about their time at the American Center for Reproductive Medicine.

Lindsay Trujillo
David Collins
Rachel Thomas
Jason Peng
Chloe Ong
Rohan Peer

Read for yourself about the interns' experiences, their testimonials and their evaluation of the program.

Mentor Feedback (2013 Mentors)

Click on the pictures below to hear what our Mentors have to say about their time at the American Center for Reproductive Medicine.

Dr. Stefan du Plessis
Dr. Damayanthi Durairajanayagam
Dr. Saad Alshahrani

Read for yourself the letters of reflection from our Mentors on their Mentorship experience during the summer program.

Letters from Dr. du Plessis, Dr. Tvrdá, Dr. Ayaz, Dr. Gunes, Tina Virk and Kim Ly.