Contact us:
800.223.2273 Ext. 49485
Andrology Lab appointments:
800.223.2273 Ext 48182 or 216.444.8182

Cleveland Clinic - Ranked One of America's Top Hospitals

Program Director


Dr. Ashok Agarwal

Professor, Lerner College of Medicine,
Case Western Reserve University
Director, Andrology Center
Director, American Center for Reproductive Medicine
Staff, Glickman Urological & Kidney Institute, and
Ob-Gyn and Women's Health Institute,
Anatomic Pathology, and Immunology
Cleveland Clinic
10681 Carnegie Ave., X11
Cleveland, Ohio 44195 USA
Tel: 216-444-9485; Fax: 216-445-6049
ResearchGate Profile
LinkedIn Profile
Wikipedia Profile
Dr. Agarwal's Twitter: @AshokAgarwalCCF
ACRM's Twitter: @CleClinReproMed
ACRM's Facebook: Cleveland Clinic Center for Reproductive Medicine

About Us


The American Center for Reproductive Medicine is a research program of the Cleveland Clinic Glickman Urological & Kidney Institute (rated as No. 1 in the country by the US News and World Report). Our Center is rated as a leading center of excellence at the world-class Cleveland Clinic, which is recognized by U.S. News & World Report as one of the nation's best hospitals, ranked as No. 2 in the country. Over the past 25 years our Center has trained over 1,000 pre-med/ medical students, physicians, scientists and biologists from more than 50 countries.

Center's summer internship offers a unique opportunity for students interested in gaining a research experience in human fertility and reproductive biology and the opportunity of working with world-renowned scientists and researchers. Members of our staff publish frequently in most respected journals, are invited guest speakers at important scientific/ medical meetings and courses around the world and are active in the leading professional societies in the exciting field of human reproductive medicine. For an up to date list of our publications, kindly visit A Scopus Citation Report of Research Publications by the American Center for Reproductive Medicine from 1993 to 2017 is available here.

Research Position Available Dr. Agarwal's Biosketch Citation Metrics 25 years of CRM Research Global Author Ranking Books Published

Program Goals and Benefits



Summer Intership Covers

The American Center for Reproductive Medicine at Cleveland Clinic offers a unique and exciting summer internship opportunity for highly motivated, academically oriented medical or undergraduate students interested in a career in medicine.

The center provides an excellent environment to learn the art of scientific writing in medicine. This unsurpassed experience gives participants the opportunity to:

  • Immerse themselves in a state-of-the-art research environment
  • Be mentored by renowned researchers at a world-class medical institution
  • Develop a strong foundation for pursuing a career in academic medicine

The program's goal is to encourage students to consider a career in medicine, whether in reproductive medicine or any other specialty of their choosing. To this end, we have designed an exceptional summer internship program to provide students a wide range of experiences.

During this 4-week program, participants will:

  • Work alongside reproductive scientists and clinicians in learning about basic laboratory techniques in a real laboratory environment.
    Some of the laboratory techniques learned by the Summer Interns of 2019 included:
    1. Measuring sperm concentration and motility in semen samples for semen analysis
    2. Demonstration of leukocytospermia for cases of infection
    3. Evaluation of sperm vitality by eosin-nigrosin and hypoosmotic swelling test to check for sperm membrane integrity
    4. Evaluation of sperm morphology according to World Health Organization 5th edition guidelines
    5. Demonstration of sperm preparation techniques for intrauterine insemination
    6. Demonstration of sperm cryopreservation for long term storage of semen samples for fertility preservation
    7. Demonstration of sperm DNA fragmentation by TUNEL assay
  • Interact with male infertility specialists and urologists.
  • Participate in daily didactics, research meetings, and group discussions.

Students will develop a strong understanding of how reproductive research is conducted. Participants will also learn how to:

  • Record laboratory results and conduct preliminary statistical analysis
  • Present results of laboratory training in departmental meetings
  • Prepare and present PowerPoint talks
  • Hone their public speaking skills

Some of the writing projects offered to the 2019 Summer Interns include:

  1. The role of infections and leukocytes in male infertility
  2. Are antioxidants a viable treatment option for male infertility?
  3. Diagnostic value of routine semen analysis in clinical andrology
  4. Diagnostic value of advanced semen analysis in evaluation of male infertility
  5. Evaluation of seminal oxidation-reduction potential in male infertility
  6. Sperm selection strategies and their impact on ART outcomes

Summer Intern Authors

These research articles were published by the ACRM which co-authored summer interns between 6 months to 1 year after graduating from their summer internship.

The articles from the 2014 class were selected for publication in the following book.
Proteomics in Human Reproduction (Ashok Agarwal, Luna Samanta, Ricardo P. Bertolla, Damayanthi Durairajanayagam, Paula Intasqui) ISBN: 978-3-319-48418-1 (Print)
Summer Intern Author: Carolina Cirenza
This Brief explores the use of proteomics as a tool for biomarker discovery in human reproduction and summarizes current findings and trends of proteomic studies in both male and female infertility. This simplifies this important but complex topic and equips the novice reader with sufficient background information on the use of proteomics in human reproduction. The up-to-date scenario on proteomic investigations will also appeal to researchers and post-graduate students looking to keep abreast with the latest developments in reproductive research.

Oxidative Stress in Human Reproduction - Shedding Light on a Complicated Phenomenon (Ashok Agarwal, Rakesh Sharma, Sajal Gupta, Avi Harlev, Gulfam Ahmad, Stefan S du Plessis, Sandro C. Esteves, Siew May Wang, Damayanthi Durairajanayagam) ISBN: 978-3-319-48425-9 (Print)
Summer Intern Authors: Mohamed Iesar Abdelaziz, Muna M. Abuayyash, Ghada Al Hayaza, Luay AlKattan, Saad AlQasem, Rakan Alsaad, Fares Bamajbour, Eiad Habib, Zeina Kayali, Deepak Kumar, Mohammad Nouth, Yash Sarda, Amolak S. Dhillon, Nirvika Singh, My Tran
This book discusses the role of oxidative stress in the reproductive system. The book reviews endogenous sources, methods of determining its levels in body fluid/tissues, the physiological roles of ROS, as well as its negative effects on the human reproductive processes. Also discussed are multiple extrinsic factors that could induce oxidative stress in the reproductive system.
Hot off the Press: Latest High Impact Publication(s) by Intern(s)!

Ashok Agarwal and Albert Danh Bui

Published in Investigative and Clinical Urology, Date Published: November 02, 2017.

Summer Intern Author: Albert Danh Bui


Ashok Agarwal, Emily Qiu and Rakesh Sharma

Published in Arab Journal of Urology, Date Published: 23 December 2017.

Summer Intern Author: Emily Qiu


Albert Danh Bui, Rakesh Sharma, Ralf Henkel and Ashok Agarwal

Published in Andrologia (Impact Factor = 1.588), Date Published: 11 April 2018.

Summer Intern Author: Albert Danh Bui


Browse Research Publications by Interns

2017 Interns'
2016 Interns'
2015 Interns'
2014 Interns'
2013 Interns'
2012 Interns'
2011 Interns'
2010 Interns'
2009 Interns'
2008 Interns'

Additional Benefits of Internship


A unique aspect of this internship is the emphasis placed by the program on cultivating soft skills and imbibing professionalism in all participants. Skills honed during the internship include:

  • leadership
  • volunteerism
  • time management
  • effective communication
  • public speaking and presentation skills

These skills and abilities are highly valued and have a prolonged impact on participants, especially as they pursue their goals and develop careers.

The intangible mix of skills nurtured during our internship sets our interns distinctly apart from their peers and empowers them to:

  • be highly competitive in their interviews for medical school, residency or jobs
  • perform better at public speaking opportunities
  • be stronger candidates when being considered for work positions

Among the 25 fundamental values weaved through the internship syllabus are:

The teaching-learning modalities used to impart these values include:

  • 1. Mentorship
  • 2. Role modeling
  • 3. Demonstrations
  • 4. Small-group sessions
  • 5. One-on-one discussions
  • 6. Individualized coaching


Summer Internship


Who can apply?

Apply Online Q&A

Undergraduate students, medical students, residents, and recent graduates.

Both local (US nationals) and foreign (international) applicants are welcome to apply.

How to apply:

Our selection procedure for summer internship positions is highly competitive. Twelve students were selected to participate in our program in the summer of 2019. Interested applicants should submit the following:

  • Recent curriculum vitae/resume
  • At least two recent letters of recommendation from advisors, teachers, or persons who have a firsthand knowledge of the candidate. The following is not acceptable: LORs sent as an e-mail and not printed on official letterhead, not carrying a signature, letters written more than 6-8 weeks before the date of submission. What is acceptable: LORs submitted via e-mail as scanned files either directly by the referee or a candidate. Please see the application page for further guidelines.
  • Address and telephone number for a personal interview
  • A 500-word personal statement
  • Proof of medical insurance
  • A letter stating that the participant has the necessary funding to support him/herself for the 4-week program (the internship is not funded and no financial support is available). This letter could be written by the candidate.
  • An application processing fee of USD $150.00 in the form of a money order or certified bank check only - payable to "2019 Internship in Reproductive Medicine". This fee is non-refundable.
  • A non-refundable course fee of USD $4,500.00 will be required from candidates accepted for the internship. This fee may be submitted as a money order or certified bank check (no personal checks) made payable to "2019 Internship in Reproductive Medicine". Overseas candidates should review the course fee by clicking here.

Where to submit:

Program Director
American Center for Reproductive Medicine
Cleveland Clinic
10681 Carnegie Avenue, X11
Cleveland, OH 44195 USA
Tel: (216) 444-9485; Fax: (216) 445-6049


Application Deadline: March 13th, 2020

Internship Dates: July 6th to 31st, 2020

Other Important Information:

  • Foreign students and graduates are welcome to apply.
  • Research work conducted during the internship may qualify for undergraduate course credit(s). Interested participants should check with their academic advisers.
  • Successful completion of internship results in the award of a Certificate of Research Training from the American Center for Reproductive Medicine.

Expectations and Grading Criteria




Daily attendance will be taken. Points will be deducted from your participation grade for unexcused absences or arriving significantly late.

The grade scale is: 90-100% A
80-89% B
70-79% C
60-69% D
59% and below: F

Continuous assessment will be used to evaluate the different core competencies of the Internship. The Mentors will assess these components using specific scoring tools and score sheets on a continuous basis throughout the 4 weeks.

Click image for larger view

1. Participation/Theoretical Lectures:

Criteria to be evaluated include:
  1. Compulsory class attendance
  2. Participation
  3. Quiz Score
  • The Male Reproductive System
  • The Female Reproductive System
  • Introduction to Infertility, Endocrinology, Idiopathic Infertility and Varicocele
  • Laboratory Evaluation of Male Infertility
  • Advances in Microsurgery Techniques
  • Endocrinological Causes of Male Infertility and their Management
  • Impact of Oxidative Stress and the Role of Oxidation Reduction-Potential in Male Infertility
  • Fertility Preservation and Cryopreservation
  • Ethical Approach to Reproductive Medicine
  • Genetic Causes of Male Infertility
  • Proteomics of Male Infertility

2. Scientific Writing - Three evaluation opportunities

Criteria to be evaluated include:
  1. Completion of 1st draft
  2. Plagiarism report
  3. Use of Figures, Tables, Diagrams
  4. Reference list and Endnote Library
  5. Innovative writing skills
  6. Quality of manuscript
  • Publish or Perish: Tips for Publishing in a Peer-reviewed Scientific Journals
  • The Resources Available to Help Authors to Write
  • Ethical Issues in Publications – Authorship and Plagiarism

3. Practical Training - Three evaluation opportunities

Criteria to be evaluated include:
  1. Training skills
  2. Andrology practical training knowledge
  3. Teamwork
  4. Data Entry
  5. Interpretation of Data
  • Lab Safety, Pipetting Skills
  • Demonstration of Manual Semen Analysis
  • Manual Semen Analysis: Counting Accubeads
  • Manual Semen Analysis: Concentration and Motility
  • Leukocytospermia Test, White Blood Cells, Semen Analysis
  • Sperm Vitality: Hypoosmotic Swelling (HOS) Test; Eosin-Nigrosin Stain, Preparation of Smears
  • Scoring Smears for Sperm Vitality; Preparation of Morphology Smears
  • Introduction to Advanced Lab Techniques in Andrology: TUNEL, ROS, TAC and ORP
  • Sperm Preparation

4. Applied Biostatistics

  • Distinguish between parametric and non-parametric data and apply relevant subsequent tests
  • Apply simple statistical analyses such as t-test or Mann-Whitney test for comparisons
  • Apply ROC curve analyses
  • Perform trend analyses
  • Apply simple statistical analyses such as t-test or Mann-Whitney test for comparisons
  • Apply ROC curve analyses
  • Perform trend analyses
  • Understand method comparisons
  • Sample size calculations

5. Presentation Skills - Three evaluation opportunities

Criteria to be evaluated include:
  1. Delivery style
  2. Organization Clarity/Knowledge
  3. Slide quality
  4. Time management
  • Understand how to organize the content of a scientific presentation
  • Apply the 6 common tips of effective public speaking
  • Apply the do’s of public speaking
  • Know the don’ts of public speaking

Determination of the class participation/preparation grade will be based on the judgment of the effort the student puts into the course, and his/her growth in understanding (i.e. learning). Evaluation is based on attendance, preparation for class, participation in class, and the quality, creativity, consistency, and completeness of work. It is very unlikely that anyone who is chronically late (without a reasonable explanation), or has more than one unexcused absence, will receive an “A” grade. Attendance will be taken daily and points will be deducted for unexcused absences and late arrival. Documentation from a health care provider or The University Health Service, etc will be necessary to excuse absence.

Facilities & Resources


The Laboratories
Research and Clinical Laboratories occupy over 5000 square feet of workspace with state-of-the-art instruments and facilities for advanced research in fertility preservation in patients with cancer, proteomics of male and female infertility and molecular markers of oxidative stress and DNA integrity.

Equipment and Instrumentation
Instruments available in our facility include: computer assisted semen analyzers, luminometer for oxidative stress measurements, Accuri BD C6 flow cytometer, equipment for western blot, culture room equipped with a sterile hood, several incubators, microscopes, and Narishige micromanipulator fitted on an inverted phase-contrast microscope, spectrophotometers, ELISA plate reader, centrifuges, liquid nitrogen storage tanks, programmable freezers, cold room, etc.

Core Laboratories
The laboratory has ready access to over a dozen highly-specialized core laboratories within the Cleveland Clinic Lerner Research Institute. These include: proteomics, metabolomics, genomics, molecular biotechnology, molecular screening, flow cytometry, mass spectrometry, translational research, digital imaging and electron microscopy, etc. For more information on these core laboratories, please visit:

IT Equipment
Along with office supplies, the office space for Fellows is equipped with over 2 dozen computers with laser printers, scanners, copiers, and all the necessary software programs. All computers in the Center are connected to the Cleveland Clinic's intranet that provides direct access to most online journals related to the field of medicine, urology, reproductive medicine, andrology, oby-gyn, etc.

A large collection of scientific journals, electronic journals/books, and other databases are available through the resourceful Cleveland Clinic Alumni Library. Specialized Medical Librarians are ever willing to help in research and use of electronic databases. Statistical research support is readily available from a team of biostatisticians working in the Department of Quantitative Health Sciences (QHS). Services for the design and creation of medical illustration for publication purposes are provided by The Center for Medical Art and Photography (CMAP) Arts and Photo also aid in the preparation of research posters and lecture slides for presentations at national meetings.



Andrology Lab Booklet

Graduating Interns (2019)


Amin Alayyan

Royal College of Surgeons in Ireland-Medical University of Bahrain


Catalina Barbarosie

University of Buchrest


Sulagna Dutta

MAHSA University


Renata Finelli

University of Rome La Sapienza


Stephanie Nunez Gonzalez

University of Puerto Rico
Puerto Rico


Concetta Iovine

University of Campania Luigi Vanvitelli


Kruyanshi Master

Vellore Institute of Technology


Huijun Park

Angelo State University


Kathy Robert

Rajiv Gandhi University of Health Sciences


Pallav Sengupta

MAHSA University


Organizing Faculty 2019

Ashok Agarwal

Professor, Cleveland Clinic Lerner College of Medicine, Director, Andrology Center, Director, American Center for Reproductive Medicine and Director, 2016 Summer Internship Program


Manesh Kumar Panner Selvam

Research Fellow at the American Center for Reproductive Medicine


Sajal Gupta

Assistant Professor, Cleveland Clinic Lerner College of Medicine, Assistant Research Coordinator, American Center for Reproductive Medicine, Supervisor, Andrology Center


Rakesh Sharma

Associate Professor, Cleveland Clinic Lerner College of Medicine, Research Coordinator, American Center for Reproductive Medicine, Coordinator, Andrology Center


Ralf Henkel, Ph.D

Visiting Faculty and Summer Internship Coordinator at the American Center for Reproductive Medicine


Leisegang, Kristian

Acting Director of the School of Natural Medicine, University of the Western Cape (UWC)


Kruyanshi Master

Assistant Summer Internship Coordinator, American Center for Reproductive Medicine, Cleveland Clinic




Ashok Agarwal PhD, HCLD (ABB)
Rakesh Sharma, Ph.D
Research Coordinator
Sajal Gupta, MD, TS (ABB)
Assistant Research Coordinator
Amy Moore, B.A.
Nicholas Farber, M.D.
Guest Speaker
Kristian Leisegang, Ph.D
Guest Speaker
Loren Hackett, MLIS
Medical Librarian
Manesh Kumar Panner Selvam, Ph.D
Research Fellow
Ralf Henkel, Ph.D, Habil
Summer Internship Coordinator
Avraham Harlev, M.D.
Guest Speaker
IVF Specialis

Scientific Presentations (2019)

Presentations 201

The summer interns gave a 15 minute presentation regarding their Scientific Writing Topic on the 2019 Summer Internship Graduation Program on Thursday, August 2nd, 2019. The presentations were held from 8:20am to 12:20 pm. The audience comprised of leaders in the field of reproductive medicine, and interns.


Award Ceremony


2019 Group Photos 2019 Summer Internship 2019 Laboratory Shoot Scientific Presentations and Guest Lectures Awards Ceremony

Student Feedback

Click on the pictures below to hear what our former interns have to say about their time at the American Center for Reproductive Medicine.

Lindsay Trujillo
David Collins
Rachel Thomas
Jason Peng
Chloe Ong
Rohan Peer

Read for yourself about the interns' experiences, their testimonials and their evaluation of the program.

Mentor Feedback

Click on the pictures below to hear what our Mentors have to say about their time at the American Center for Reproductive Medicine.

Dr. Stefan du Plessis
Dr. Damayanthi Durairajanayagam
Dr. Saad Alshahrani
Dr. Kristian Leisegang

Read for yourself the letters of reflection from our Mentors on their Mentorship experience during the summer program.

Letters from Dr. du Plessis, Dr. Tvrdá, Dr. Ayaz, Dr. Gunes, Tina Virk and Kim Ly.