Inherited Colorectal Cancer Registries
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Welcome to the David G. Jagelman Inherited Colorectal Cancer Registries web site. Here you will find information on all forms of inherited colorectal cancer, including Hereditary Non-polyposis Colorectal Cancer (HNPCC), Familial Adenomatous Polyposis (FAP), Peutz-Jegher’s Syndrome (PJS), and Juvenile Polyposis (JP).

In 1979, The Familial Polyposis Registry was founded by Dr. Jagelman, a colorectal surgeon at the Cleveland Clinic. Ten years later the registry was expanded to include all syndromes of inherited colorectal cancer. Now the David G. Jagelman Registries are among the largest in the world. Our staff at the registry work with thousands of diagnosed and at risk individuals to support them in their experiences with this disease. In addition, they work to educate the public on preventative measures that can lead to a healthy and full life. We are actively involved in many research areas involving the inherited colorectal cancer syndromes.

If inherited colorectal cancer has effected you or a family member, we encourage you to explore this site. Our website also reviews the different forms of inherited colon cancer, the genetics behind them, and the diagnosis and treatment options available. You will learn more about the Jagelman Registries here at The Cleveland Clinic Foundation, the services we offer, as well as how to join. If you have a family history of colon cancer, but are not sure of your own risk status, we strongly encourage you to explore this portion of the website. Through colorectal cancer screening and surveillance colon cancer is both preventable and curable.

In addition to this web site, we offer patients with a dominantly-inherited colon cancer syndrome the chance to consult with our specialists in our inherited colon cancer high-risk clinic. This clinic is held once a month on Wednesday afternoon in the Digestive Disease Center. Patients have the opportunity to consult with Drs. Burke, Church, Clark, genetic counselors, and the Jagelman Registries Registrar. Additionally, they may undergo any necessary procedures or genetic testing on the day of their consultation.

We hope you find this site and the information provided useful. If you would like to contact us directly, the information for doing so is provided under the “Contact Us” section.


James M. Church, M.D.
Director, David G. Jagelman Inherited
Colorectal Cancer Registries

Carol Burke, M.D.
Director, Center for Colon Polyps and Cancer
Department of Gastroenterology and Hepatology


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