NATION’S 1ST
UTERUS TRANSPLANT

February 2016. Multidisciplinary surgical team performs the nation’s first uterus transplant during a nine-hour surgery Feb. 24, 2016. The procedure is the first in a pioneering clinical trial of uterine transplantation in women of reproductive age with uterine factor infertility (UFI). It is the first such clinical trial by a U.S. medical center.

March 9, 2016: An important update on Cleveland Clinic’s 1st uterus transplant

April 8, 2016: Update on uterus transplant complications

How it Works

Uterus transplantation is a major feat of microsurgical engineering. Here's how it's done.

Watch the Process

Come inside the operating room, where skill, concentration, and teamwork come together to work a medical miracle.

Path to Parenthood

Candidates get in-depth screening

Must be 21-39 with
uterine factor infertility (UFI)



Evaluated by team of experts

Donor search begins

Ages 18-40 with a healthy uterus

Next of kin must consent

IVF starts

Patient’s ovaries stimulated

Eggs removed & fertilized in lab

6-10 embryos frozen

Prep and transplant

Anti-rejection drugs started

Donor uterus & blood supply transplanted into patient’s pelvis

IVF continues

In a few months, periods begin

In 12 months, uterus heals

Embryos implanted one by one

Goal: 1-2 pregnancies

Pregnancy monitored

Anti-rejection drugs required throughout

Monthly biopsies check for rejection

Motherhood

Baby delivered by C-section

Donor uterus removed after 1-2 babies

Anti-rejection drugs stop

Read more from Cleveland Clinic

Meet the team

They've spent a lifetime preparing for moments like this: brilliant surgeons, doctors, and specialists at the top of their game.

Kareem Abu-Elmagd, MD, PhD

Transplant Surgeon

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Trudy Aquilina

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Kathy Coffman, MD

Psychiatry

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Bijan Eghtesad, MD

Transplant Surgeon

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Tommaso Falcone, MD

Gynecologic Surgeon

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Ruth Farrell, MD

Bioethics

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Rebecca Flyckt

Gynecologic Surgeon

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John Fung, MD, PhD

Transplant Surgeon

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Sumita Khatri, MD

Patient Advocacy

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Eric Kodish, MD

Bioethics

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Shana Maikhor

Research Coordinator

Stacy Payne

Research Coordinator

Uma Perni, MD

Gynecologic Surgeon

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Debra Priebe

Transplant Coordinator

Chrstiano Quintini, MD

Transplant Surgeon

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Chris Roddy

Research Specialist, Florida

Janelle Romond

Psychiatry

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Terry Roncagli

Social Work

Debbie Sears

Nurse Manager, Florida

Michael Sprague, MD

Gynecologic Surgeon, Florida

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Karen Steckner, MD

Anesthesiologist

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Susan Thomas

Research Administrator

Andreas Tzakis, MD

Transplant Surgeon

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Megan Villarreal

Research Coordinator

Steven Zimberg, MD

Gynecologic Surgeon, Florida

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