Brian has been a partner of Domain since 1988, where he has led innovative investments not only in life sciences companies but also in establishing and directing new initiatives, such as the collaboration with Domain and Rusnano. Since joining Domain, he has served on the board of directors of more than 35 private and public companies and has been Chairman of five. He is currently on the board of two public companies, Orexigen Therapeutics and REVA Medical. Prior to Domain, Brian spent six years at Rorer Group (now part of Sanofi-Aventis). As President of Rorer from 1986 to 1988, he was the primary architect of the company's strategic shift to pharmaceuticals that resulted in a doubling of annual sales to approximately $1 billion. Prior to that, Brian was President of Survival Technology, a start-up medical products company whose sales growth placed it in the top ten of the Inc 100. He has also held management positions with Howmedica, Howmet Corporation, and New York Telephone. He received his BA in mathematics from Colgate University and his MBA from Harvard Business School. Currently, Brian serves on the Board of Directors and is Chairman at the Center for Venture Education (Kauffman Fellows Program) and on the La Jolla Playhouse Board of Trustees. Brian is also on the Venture Advisory Board of the Skolkovo Foundation. He is Former Chair and currently serves on the Board of Trustees of the Wistar Institute, a leader in preclinical bio-medical research in the non-profit sector. Brian has served as both President and Chairman of the National Venture Capital Association. He is a Trustee Emeritus of Germantown Academy and is a former Trustee of the University of Pennsylvania School of Nursing and the Burnham Institute for Medical Research. He is also a former board member of the industry associations representing the medical device industry as well as the association representing consumer pharmaceuticals.