Innovations at the Cleveland Clinic
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Recently Issued Patents : 2004

  DE60107401C0: Chronic Performance Control System for Rotodynamic Blood Pumps
Inventors: Alexander Medvedev, Ph.D., Leonard Golding, M.D., and Alexander Massiello
Issue Date: 12/30/2004
Brief Description: Cardiac assist apparatus chronic performance control system for rotodynamic blood pump has controller directing power to drive unit in response to sensed current, voltage and rotational frequency waveforms.

  DE69827266C0: System and Method for Minimally Invasive Surgery with Vacuum-Assisted Venous Drainage
Inventors: Delos M. Cosgrove, M.D., Robert C. Foster, Ronald Cambron, Francis Vijay, Richard Knight, and Ken Litzie
Issue Date: 12/2/2004
Brief Description: The present invention relates generally to a reduced prime volume cardiopulmonary bypass system that is useful in connection with minimally invasive cardiovascular surgical procedures, and more specifically, vacuum-assisted venous drainage systems and associated minimally invasive surgical methods.

  EP1267958B1: Chronic Performance Control System for Rotodynamic Blood Pumps
Inventors: Alexander Medvedev, Ph.D., Leonard Golding, M.D., and Alexander Massiello
Issue Date: 11/24/2004
Brief Description: Cardiac assist apparatus chronic performance control system for rotodynamic blood pump has controller directing power to drive unit in response to sensed current, voltage and rotational frequency waveforms.

US6810753: Displacement Transducer
Inventors: Antonio Valdevit, Helen Kambic, Theodore Elster, and Ahmed El-Said
Issue Date: 11/2/2004
Brief Description: A measurement device capable of measuring very tiny strains on the order of 100 µm or less, with a resolution of at least 10 µm in both the positive and negative direction.

  EP1003575B1: System for Minimally Invasive Surgery with Vacuum-Assisted Venous Drainage
Inventors: Delos M. Cosgrove, M.D., Robert C. Foster, Ronald Cambron, Francis Vijay, Richard Knight, and Ken Litzie
Issue Date: 10/27/2004
Brief Description: The present invention relates generally to a reduced prime volume cardiopulmonary bypass system that is useful in connection with minimally invasive cardiovascular surgical procedures, and more specifically, vacuum-assisted venous drainage systems and associated minimally invasive surgical methods.

US6802806: Apparatus for Use with an Inflow Cannula of Ventricular Assist Device
Inventors: Patrick M. McCarthy, and Ji-Feng Chen
Issue Date: 10/12/2004
Brief Description: Conduit assembly used with inflow cannula for directing blood flow from heart to ventricular assist device (VAD). Assembly has connecting nuts which individually couple opposite ends of conduit to corresponding portions of inflow cannula.

  AU0777200B2: Continuous Particle and Molecule Separation with an Annular Flow Channel
Inventors: Maciej Zborowski, Ph.D., Jeff Chalmers, and Lee R. Moore
Issue Date: 10/7/2004
Brief Description: Annular separation channel for use in separating particles, e.g. metals, includes two sequential spaces respectively bonded to cylindrical walls, and third space partially bound by two walls.

US6800087: Blanket System for Temperature Regulation of a Patient
Inventors: Francis A. Papay, M.D., and Stefan Budac
Issue Date: 10/5/2004
Brief Description: Blanket system maintains patient body temperature before, during, and after both surgical and non-surgical procedures. System includes cover blanket and air blower/vacuum system.

US6798199: Method for Synchronizing Magnetic Resonance Imaging Data to Body Motion
Inventors: Andrew C. Larson, M.D. Orlando P. Simonetti, Richard D. White, and Gerhard Laub.
Issue Date: 9/28/2004
Brief Description: Magnetic resonance images are synched to patient motion (beating heart, expanding lungs, etc.) by extracting timing information directly from the MR image data rather than collecting additional timing data.

  AU0776527B2: Intravascular Ultrasonic Analysis Using Active Contour Method and System
Inventors: Jon D. Klingensmith, David Geoffrey Vince, M.D., and Raj Shekhar
Issue Date: 9/16/2004
Brief Description: Determining boundary contour of blood vessel by displaying ultrasound images, selecting control points on boundary, and interpolating between control points to generated boundary contour.

US6790372: Microneedle Array Module and Method of Fabricating the Same
Inventors: Shuvo Roy, Ph.D., and Aaron J. Fleischman, Ph.D.
Issue Date: 9/14/2004
Brief Description: Microneedle array module useful for drug delivery, comprises substrate and microneedles affixed to and protruding outwardly from front surface of substrate.

  DE69825150C0: Rotodynamic Pump with Non-Circular Hydrodynamic Bearing Journal
Inventors: Leonard Golding, M.D., and William Smith
Issue Date: 8/26/2004
Brief Description: Rotodynamic pump with non-circular hydrodynamic bearing journal, suitable for use as heart or blood pumps or as ventricular assist devices.

  EP0968369B1: Rotodynamic Pump with Non-Circular Hydrodynamic Bearing Journal
Inventors: Leonard Golding, M.D., and William Smith
Issue Date: 7/21/2004
Brief Description: Rotodynamic pump with non-circular hydrodynamic bearing journal, suitable for use as heart or blood pumps or as ventricular assist devices.

US6762038: Mutant Cell Lines and Methods for Producing Enhanced Levels of Recombinant Proteins
Inventors: Robert H. Silverman, Ph.D., Bryan R. G. Williams, Fulvia Terenzi, Aimin Zhou, and Sandy Der
Issue Date: 7/13/2004
Brief Description: New isolated mutant mouse cell having a homozygous disruption in the RNase L and PKR genes for producing high levels of exogenous, recombinant protein such as may be used in protein therapeutics.

US6755813: Apparatus and Method for Performing Thrombolysis
Inventors: Kenneth Ouriel, M.D., Harry B. Goodson, and Roy K. Greenberg, M.D.
Issue Date: 6/29/2004
Brief Description: Invention performs thrombolysis by introducing an infusate into the lumen via catheter with a series of infusion ports spaced axially along the length of the infusion portion of the catheter.

US6752986: Composition and Methods for Affecting Metallocorrinoid Uptake
Inventors: Joseph A. Bauer, Ph.D., and Daniel J. Lindner, M.D., Ph.D.
Issue Date: 6/22/2004
Brief Description: Invention enhances uptake and availability of metallocorrinoids which is useful in the prevention of conditions resulting from low expression or activity of proteins and other conditions that benefit from enhanced metallocorrinoid uptake.

US6749619: Apparatus and Method for Eliminating Dislodged Thrombus
Inventors: Kenneth Ouriel, M.D., Harry B. Goodson, and Roy K. Greenberg, M.D.
Issue Date: 6/15/2004
Brief Description: Apparatus for eliminating dislodged thrombus in a blood vessel. Apparatus has catheter having infusion ports which deliver thrombolytic fluid to dissolve dislodged thrombus trapped in filter.

US6749568: Intraocular Pressure Measurement System Including a Sensor Mounted in a Contact Lens
Inventors: Aaron J. Fleischman, Ph.D., Shuvo Roy, Ph.D., Hilel Lewis, M.D.
Issue Date: 6/15/2004
Brief Description: Intraocular pressure measurement device fabricated from a contoured contact lens and using telemetry to send output signals.

US6732739: Minimally Invasive Cardiac Surgery Procedure
Inventors: Delos M. Cosgrove, M.D.
Issue Date: 5/11/2004
Brief Description: Method of performing a minimally invasive cardiac surgery on a patient (e.g. aortic valve replacement). Method includes making a parasternal incision across a predetermined number of costal cartilage and exercising one or more costal cartilage to provide access to portion of the heart.

US6723131: Composite Bone Marrow Graft Material with Method and Kit
Inventors: George F. Muschler, M.D.
Issue Date: 4/20/2004
Brief Description: A composite bone marrow graft material derived from non-anticoagulated bone marrow aspirate which improves graft efficacy and method for preparing the graft material.

US6725081: Intravascular Radiation Delivery Device
Inventors: Jay P. Ciezki, M.D., Eugene J. Jung, Jr., Eric J. Lee, Emin M. Tuzcu, M.D., James D. Savage, and Martin S. Weinhous, Ph.D.
Issue Date: 4/20/2004
Brief Description: Precision method for delivering radiation dosage to a blood vessel site via adjustable catheter.

US6706005: Apparatus and Method for Assessing Loads on Adjacent Bones
Inventors: Shuvo Roy, Ph.D., Aaron J. Fleischman, Ph.D., Edward C. Benzel, M.D., and Lisa Ferrara
Issue Date: 3/16/2004
Brief Description: Micro-Electro-Mechanical Systems (MEMS) sensor that monitors the loads on adjacent bones in vivo remotely via telemetry.

US6703632: Radiation Shield
Inventors: Roger M. Macklis, M.D., Jason Sohn, and Twyla Willoughby
Issue Date: 3/9/2004
Brief Description: A shape conforming radiation shield, provided with safety dosimeters and a fail-safe system, for patients undergoing radiotherapy treatment.

US6689168: Method and Apparatus for Stabilizing Adjacent Bones
Inventors: Isador H.Lieberman, M.D.
Issue Date: 2/10/2004
Brief Description: A bone screw with helically-shaped spikes for stabilizing vertebral bodies while they fuse together.

US6687422: Discrete Image Data Interpolation using Sub-Unity Shift
Inventors: Qin-Sheng Chen, Ph.D. and Martin S. Weinhous, Ph.D.
Issue Date: 2/3/2004
Brief Description: Digital image interpolation method useful for medical imaging such as computer tomography and magnetic resonance imaging.

US6682537: Apparatus and Method for Capturing a Wire in a Blood Vessel
Inventors: Kenneth Ouriel, M.D., and Daniel Clair, M.D.
Issue Date: 1/27/2004
Brief Description: A tube apparatus for capturing a wire within a lumen of a blood vessel; also includes ability to constrict wire loop.

US6682490: Apparatus and Method for Monitoring a Condition Inside a Body Cavity
Inventors: Shuvo Roy, Ph.D., Kenneth Ouriel, M.D., and Aaron Fleischman, Ph.D.
Issue Date: 1/27/2004
Brief Description: Micro-Electro-Mechanical Systems (MEMS) sensor to monitor conditions inside a body cavity, such as AAA, remotely via telemetry.