Lower Extremity Ulcers
What are ulcers?
Ulcers are wounds or open sores that will not heal or keep returning.
What are the symptoms of ulcers?
Ulcers may or may not be painful. The patient generally has a swollen leg
and may feel burning or itching. There may also be a rash, redness, brown
discoloration or dry, scaly skin.
What are the types of leg and foot ulcers?
The three most common types of leg and foot ulcers include:
- Venous stasis ulcers
- Arterial (ischemic ulcers)
- Neurotrophic (diabetic)
Ulcers are typically defined by the appearance of the ulcer, the ulcer
location, and the way the borders and surrounding skin of the ulcer look.
1. Venous stasis ulcers
Venous ulcers are located below the knee and are primarily found on the
inner part of the leg, just above the ankle.
The base of a venous ulcer is usually red. It may also be covered with yellow
fibrous tissue or there may be a green or yellow discharge if the ulcer is
infected. Fluid drainage can be significant with this type of ulcer.
The borders of a venous ulcer are usually irregularly shaped and the
surrounding skin is often discolored and swollen. It may even feel warm or hot.
The skin may appear shiny and tight, depending on the amount of edema
Venous stasis ulcers are common in patients who have a history of leg
swelling, varicose veins, or a history of blood clots in either the superficial
or the deep veins of the legs. Ulcers may affect one or both legs.
Venous ulcers affect 500,000 to 600,000 people in the United States every
year and account for 80 to 90% of all leg ulcers.
2. Arterial (ischemic)
Arterial ulcers are usually located on the feet and often occur on the
heels, tips of toes, between the toes where the toes rub against one another or
anywhere the bones may protrude and rub against bed sheets, socks or shoes.
Arterial ulcers also occur commonly in the nail bed if the toenail cuts into the
skin or if the patient has had recent aggressive toe nail trimming or an ingrown
The base of an arterial or ischemic ulcer usually does not bleed. It has a
yellow, brown, grey, or black color. The borders and surrounding skin usually
appear as though they have been punched out. If irritation or infection are
present, there may or may not be swelling and redness around the ulcer base.
There may also be redness on the entire foot when the leg is dangled; this
redness often turns to a pale white/yellow color when the leg is elevated.
Arterial ulcers are typically very painful, especially at night. The patient
may instinctively dangle his/her foot over the side of the bed to get pain
relief. The patient usually has prior knowledge of poor circulation in the legs
and may have an accompanying disorder, such as those listed in the section,
"What causes leg ulcers?"
3. Neurotrophic (diabetic)
Neurotrophic ulcers are usually located at increased pressure points on the
bottom of the feet. However, neurotrophic ulcers related to trauma can occur
anywhere on the foot. They occur primarily in people with diabetes, although
they can affect anyone who has an impaired sensation of the feet.
The base of the ulcer is variable, depending on the patient's circulation. It
may appear pink/red or brown/black. The borders of the ulcer are punched out,
while the surrounding skin is often calloused.
Neuropathy and peripheral artery disease often occur together in people who
have diabetes. Nerve damage (neuropathy) in the feet can result in a loss of
foot sensation and changes in the sweat-producing glands, increasing the risk of
being unaware of foot calluses or cracks, injury or risk of infection. Symptoms
of neuropathy include tingling, numbness, burning or pain.
It is easy to understand why people with diabetes are more prone to foot
ulcers than other patients. This is why people with diabetes need to inspect
their feet and their shoes daily and wear appropriate footwear. People with
diabetes should never walk barefoot.
What causes leg ulcers?
Leg ulcers may be caused by medical conditions such as:
- Poor circulation, often caused by arteriosclerosis
- Venous insufficiency (a failure of the valves in the veins of the leg that
causes congestion and slowing of blood circulation in the veins)
- Other disorders of clotting and circulation that may or may not be related
- Renal (kidney) failure
- Hypertension (treated or untreated)
- Lymphedema (a buildup of fluid that causes swelling in the legs or feet)
- Inflammatory diseases including vasculitis, lupus, scleroderma or other
- Other medical conditions such as high cholesterol, heart disease, high
blood pressure, sickle cell anemia, bowel disorders
- History of smoking (either current or past)
- Pressure caused by lying in one position for too long
- Genetics (ulcers may be hereditary)
- A malignancy (tumor or cancerous mass)
- Certain medications
How are leg ulcers diagnosed?
First, the patient's medical history is evaluated. A wound specialist will
examine the wound thoroughly and may perform tests such as X-rays, MRIs, CT
scans and noninvasive vascular studies to help develop a treatment plan.
How are leg ulcers treated?
At The Cleveland Clinic, patients are treated by a team of world-class
experts in the Lower Extremity Wound Clinic in the Department of
Cardiovascular Medicine. This Clinic includes doctors, nurses and other medical
specialists. These experts work together to determine the cause of the problem
and develop an individualized treatment program.
The goals of treatment are to relieve pain, speed recovery and heal the
wound. Each patient's treatment plan is individualized, based on the patient's
health, medical condition and ability to care for the wound.
Treatment options for all ulcers may include:
- Antibiotics, if an infection is present
- Anti-platelet or anti-clotting medications to prevent a blood clot
- Topical wound care therapies
- Compression garments
- Prosthetics or orthotics, available to restore or enhance normal lifestyle
Venous ulcers are treated with compression of the leg to minimize
edema or swelling. Compression treatments include wearing compression stockings,
multilayer compression wraps, or wrapping an ACE bandage or dressing from the
toes or foot to the area below the knee. The type of compression treatment
prescribed is determined by the physician, based on the characteristics of the
ulcer base and amount of drainage from the ulcer.
The type of dressing prescribed for ulcers is determined by the type of ulcer
and the appearance at the base of the ulcer. Types of dressings include:
- Moist to moist dressings
- Alginate dressings
- Collagen wound dressings
- Debriding agents
- Antimicrobial dressings
- Composite dressings
- Synthetic skin substitutes
Arterial ulcer treatments vary, depending on the severity of the
arterial disease. Non-invasive vascular tests provide the physician with the
diagnostic tools to assess the potential for wound healing. Depending on the
patient's condition, the physician may recommend invasive testing, endovascular
therapy or bypass surgery to restore circulation to the affected leg.
The goals for arterial ulcer treatment include:
- Providing adequate protection of the surface of the skin
- Preventing new ulcers
- Removing contact irritation to the existing ulcer
- Monitoring signs and symptoms of infection that may involve the soft
tissues or bone
Treatment for neurotrophic ulcers includes avoiding pressure and
weight-bearing on the affected leg. Regular debridement (the removal of infected
tissue) is usually necessary before a neurotrophic ulcer can heal. Frequently,
special shoes or orthotic devices must be worn.
Wound care at home
Patients are given instructions to care for their wounds at home. These
- Keeping the wound clean and dry
- Changing the dressing as directed
- Taking prescribed medications as directed
- Drinking plenty of fluids
- Following a healthy diet, as recommended, including eating plenty of
fruits and vegetables
- Exercising regularly, as directed by a physician
- Wearing appropriate shoes
- Wearing compression wraps, if appropriate, as directed
Foot and skin care guidelines
The treatment of all ulcers begins with careful skin and foot care.
Inspecting your skin and feet is very important, especially for people with
diabetes. Detecting and treating foot and skin sores early can help you prevent
infection and prevent the sore from getting worse.
Here are some guidelines:
1. Gently wash the affected area on your leg and your feet every day with
mild soap (Ivory Snow or Dreft) and lukewarm water. Washing helps loosen and
remove dead skin and other debris or drainage from the ulcer. Gently and
thoroughly dry your skin and feet, including between the toes. Do not rub your
skin or area between the toes.
2. Every day, examine your legs as well as the tops and bottoms of your feet
and the areas between your toes. Look for any blisters, cuts, cracks, scratches
or other sores. Also check for redness, increased warmth, ingrown toenails,
corns and calluses. Use a mirror to view the leg or foot if necessary, or have a
family member look at the area for you.
3. Once or twice a day, apply a lanolin-based cream to your legs and soles
and top of your feet to prevent dry skin and cracking. Do not apply lotion
between your toes or on areas where there is an open sore or cut. If the skin is
extremely dry, use the moisturizing cream more often.
4. Care for your toenails regularly. Cut your toenails after
bathing, when they are soft. Cut toenails straight across and smooth with
a nail file.
5. If you have diabetes, it is important to see a
6. Do not self-treat corns, calluses or other foot problems. Go to a
podiatrist to treat these conditions.
7. Don't wait to treat a minor foot or skin problem. Follow your doctor's
How can ulcers be prevented?
Controlling risk factors can help you prevent ulcers from developing or
getting worse. Here are some ways to reduce your risk factors:
- Quit smoking
- Manage your blood pressure
- Control your blood cholesterol and triglyceride levels by making dietary
changes and taking medications as prescribe
- Limit your intake of sodium
- Manage your diabetes and other health conditions, if applicable
- Exercise - start a walking program after speaking with your doctor
- Lose weight if you are overweight
- Ask your doctor about aspirin therapy to prevent blood clots
Copyright 1995-2007 The Cleveland Clinic Foundation. All rights reserved