Migraine is a moderate-to-severe headache that lasts from 2 to 4 hours and usually occurs two to four times per month. (These episodic migraines are also called acute recurrent headaches.)
Migraines affect about 2% of children by age 7 and about 7 to 10% of children and adolescents by age 15. Disability from headaches – anything that interferes with activities – can be significant.
In early childhood and before puberty, migraines are more frequent among boys. In adolescence, migraines affect young women more than young men. As adults, women are three times more likely to suffer from migraines than men.
Migraines tend to run in families – that is, they are hereditary. Approximately 70% of people who have migraines also have an immediate family member (mother, father, sister or brother) who suffers, or may have suffered, from migraines in their childhood. Migraines cause a person to experience significant discomfort and disability, but they do not usually cause damage to the body. Migraines are not related to brain tumors or strokes.
Until recently, the cause of migraine was thought to be vascular – caused by the constriction and expansion of blood vessels in the brain. Today, migraine is thought to be an episodic brain malfunction –"a central nervous system (CNS) disorder" of primarily the brain and nerves, and secondarily of the blood vessels. The "malfunction" is caused, in part, by changes in the level of circulating neurotransmitters (chemicals in the CNS), and involving serotonin in particular.
* An aura is a warning sign that a migraine is about to begin. An aura usually occurs about 10 to 30 minutes before the onset of a migraine. The most common auras are visual and include blurred or distorted vision; blind spots; or brightly colored, flashing or moving lights or lines. Other auras may include speech disturbances, motor weakness or sensory changes. The duration of an aura varies, but it generally lasts about 20 minutes.
Patients with complicated migraine syndromes require a complete neurological evaluation, which may require laboratory tests and two types of imaging tests, MRI (magnetic resonance imaging) and MRA (magnetic resonance imaging of the arteries) scans. These tests allow the tissues and arteries within the brain to be seen and evaluated. Most patients with complicated migraine recover completely, and a structural abnormality is rarely found.
The key to diagnosing these migraine variants, which can be confused with other neurological syndromes, is their tendency to recur at intervals. The person does not have symptoms between attacks. Patients with migraine variants may also have a positive family history of migraine, and have a history of or develop migraine headaches.
Although symptoms can vary from person to person, the general symptoms of common and classic migraine are:
In many children and adolescents, migraines are triggered by external factors. These "triggers" vary for each person. Some common migraine triggers include:
By identifying your migraine triggers, you can take steps to avoid the trigger to decrease the frequency and severity of your migraines and make life more enjoyable.
The correct headache diagnosis is needed to develop an effective treatment plan. The most important aspect of the headache evaluation is the headache history, which should be obtained from both the headache patient and his or her parents.
The history includes a description of current and previous headaches—specifically, how the patient feels before, during, and after the headache as well as headache frequency, duration, and associated symptoms. The history includes what medications have been taken in the past, what medications are currently being taken, and which medications have worked best.
Important: The results of previously conducted studies or tests should be brought with you and given to your doctor.
After completing the medical history part of the evaluation, your doctor will perform physical and neurological examinations. After evaluating the head-ache history, physical examination and neurological examination, your doctor should be able to determine what type of headache the patient has, whether or not a serious health problem might be the cause of the headache, and if additional tests are needed—such as additional lab work, EEG, or scan. In typical patients with migraine, no additional tests or evaluations are needed as no neurological abnormalities will be found.
Basic lifestyle changes can help control migraines. Because migraines are often triggered by external factors, avoiding the known triggers whenever possible can help reduce the frequency of migraine attacks.
Biofeedback and Stress Reduction. Biofeedback helps a person learn stress-reduction skills by providing information about muscle tension, heart rate and other vital signs as a person attempts to relax. It is used to gain control over certain bodily functions that cause tension and physical pain.
Biofeedback can be used to help patients learn how their body responds in stressful situations, and how to better cope. Some people choose biofeedback instead of medications.
Other stress reduction options include counseling, yoga, and other relaxation techniques.
Medications. Headache medications can be grouped into three different categories: symptomatic relief, abortive therapy and preventive therapy. Each type of medication is most effective when used in combination with other medical recommendations, such as dietary and lifestyle changes, exercise and relaxation therapy.
Symptomatic relief—used to relieve symptoms associated with headaches, including the pain of a headache or the nausea and vomiting associated with migraine. These medications include simple analgesics (ibuprofen or acetaminophen), antiemetics (for nausea/vomiting), or sedatives (to help sleep; sleep relieves migraines). Some of these medications may require a prescription; others are available over-the-counter without the need for a prescription.
Important: If symptomatic relief medications are used more than twice a week, see your doctor. Overuse of these symptomatic medications can actually cause more frequent headaches or worsen headache symptoms.
Abortive therapy—helps to stop the headache process and to prevent migraine symptoms including pain, nausea, and light-sensitivity. They are taken at the first sign of a migraine.
Abortive medications include:
Up to 70% of migraines can be modified with the use of preventive medications. Often, however, a combination of symptomatic and preventive medications may be necessary. Patients should be started at a low dose, with the dose slowly increased over time. Medication works best when combined with lifestyle changes and patient education.
Treatment helps most children and adolescents with migraines. Fifty percent of children and adolescents report migraine improvement within 6 months after treatment. However, in about 60% of adolescents who experience their first migraine as an adolescent, the migraines continue off and on for many years.
Rehabilitation Program. Some hospitals and/or other health care facilities offer inpatient program for children and adolescents; ask your doctor if their facility offers such programs. Patients typically accepted into these programs are those who are missing school, overusing medications, and whose headache pain is controlling their lives.
Clinical Trials. Some children and adolescents with migraines don't experience headache relief despite trying many of the currently available medications. If this is the case for your child, ask your doctor about possible participation in a clinical trial. Clinical trials provide access to drugs not yet approved by the FDA. Such drugs are not available through "regular" doctors' offices; they are only available through doctors and health care organizations that have agreed to participate in the clinical trials. Your doctor will help determine if your child is an appropriate candidate for this type of research study.
These symptomatic medications are useful:
These preventive medications may be prescribed:
These symptomatic medications can be useful:
These abortive medications can be useful:
These preventive medications can be tried:
These abortive medications can be prescribed:
When headaches—and especially migraine headaches—last longer than 24 hours and other medications have been unsuccessful in managing the attacks, medication administered in an "infusion suite" can be considered. An infusion suite is a designated set of rooms at a hospital or clinic that are monitored by a nurse and where intravenous drugs are administered. The intravenous drugs are usually able to end the migraine attack. Patients' length of stay at the infusion suite can range from a several hours to all day.
Many of the medications listed in this handout have not been approved by the by the Food and Drug Administration (FDA) for use in children and adolescents with headaches. When a doctor chooses to prescribe a drug for a medical condition or for a certain patient type (eg, children) for which it has not received FDA approval, this practice is called ‘off-label' prescribing. This is a common practice in the field of medicine. It is one of the ways by which new and important uses are found for already approved drugs. Many times, positive findings lead to formal clinical trials of the drug for new conditions other than what the drug was first approved for.
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This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition. For additional health information, please contact the Center for Consumer Health Information at the Cleveland Clinic (216) 444-3771 or toll-free (800) 223-2273 extension 43771. If you prefer, you may visit www.clevelandclinic.org/health/ or www.clevelandclinicflorida.org. This document was last reviewed on: 8/1/2009