Center for Consumer Health Information, Cleveland Clinic

 

Heart Failure Medications

Taking your heart failure medications as prescribed is one of the most  important things you can do to manage your heart failure. The more you know about your medications and how they work, the easier it will be for you to stay on track.

Common types of medications used to treat heart failure include:

  • Angiotensin converting enzyme (ACE) inhibitors
  • Angiotensin II receptor blockers (ARBs)
  • Beta-blockers 
  • Digoxin 
  • Diuretics 
  • Vasodilators/Nitrates
  • Potassium or magnesium 
  • Aldosterone inhibitors (spironolactone)
  • Calcium channel blockers (for diastolic dysfunction only) 
  • Inotropic therapy

 Angiotensin enzyme (ACE) inhibitors:  

Medication Names

captopril (Capoten) enalapril (Vasotec)
lisinopril (Prinivil, Zestril) benazepril (Lotensin)
fosinopril (Monopril) ramipril (Altace)
quinapril (Accupril) perindopril (Aceon)
trandolapril (Mavik) moexipril (Univasc)

Why this medication is prescribed: ACE inhibitors are a type of vasodilator that dilate (widen) the blood vessels to improve the amount of blood the heart pumps. ACE inhibitors also increase blood flow, which will help decrease the amount of work the heart has to do. ACE inhibitors also block some of the harmful substances (angiotensin) that are produced as a result of heart failure. They also block some of the harmful responses of the endocrine system that may occur with heart failure.

ACE inhibitors are critical in the treatment of heart failure when systolic dysfunction is present. Systolic dysfunction occurs when the heart muscle doesn't contract with enough force, so there is not enough oxygen-rich blood to be pumped throughout the body. ACE inhibitors may also be prescribed for the treatment of diastolic dysfunction. Diastolic dysfunction occurs when the heart contracts normally, but the ventricle doesn't relax properly so less blood can enter the heart. Your doctor can discuss which condition is present in your heart.

When to take: These medications are usually taken on an empty stomach one hour before meals. Follow the label directions on how often to take this medication. The number of doses you take each day, the time allowed between doses and how long you need to take the medication will depend on the type of ACE inhibitor prescribed, as well as your condition.

Special directions

  • While taking this medication, have your blood pressure and kidney function checked regularly, as advised by your doctor.
  • Never stop taking your medication, even if you feel that it is not working. Your heart failure symptoms may not improve right away when taking ACE inhibitors. However, long-term use of ACE inhibitors helps manage chronic heart failure and reduces the risk that your condition will become worse.

 Food and drug interactions

  • While taking an ACE inhibitor medication, do not use salt substitutes: they contain potassium and ACE inhibitor medications cause the body to retain potassium. Learn how to read food labels to choose low-sodium and low-potassium foods. A dietitian can help you select low-sodium and low-potassium foods.
  • Over-the-counter nonsteroidal anti-inflammatory medications (like ibuprofen or naproxen) and aspirin may cause the body to retain (keep) sodium and water, and decrease the effect of an ACE inhibitor. Check with your health care provider before taking any anti-inflammatory medications.

 Side effects and how to manage them

  • Red, itchy skin rash
    Contact your doctor; do not treat the rash yourself.
  • Dizziness, lightheadedness, or faintness when you get out of bed or rise from a chair
    This side effect may be strongest after the first dose, especially if you have been taking a diuretic (water pill). Get up more slowly. Contact your doctor if these symptoms persist or are severe.
  • Salty or metallic taste, decreased ability to taste
    This effect usually goes away as you continue taking the medication.
  • Cough
    If this symptom persists or is severe, contact your doctor. Otherwise, ask your doctor what type of cough medicine you may use to control the cough.
  • Sore throat; fever; mouth sores; unusual bruising; fast or irregular heart beat; chest pain; swelling of feet, ankles, lower legs
    Contact your doctor.
  • Swelling of your neck, face and tongue
    Contact your doctor right away!
  • Signs of too much potassium in the body: confusion; irregular heartbeat; nervousness; numbness or tingling in hands, feet or lips; shortness of breath or difficulty breathing; weakness or heaviness in legs
    Contact your doctor right away.
  • If you become sick with severe vomiting or diarrhea, you may become dehydrated, which can lead to low blood pressure. 
    Contact your doctor.
    Also contact your doctor if you have any other symptoms that cause concern.

 Angiotensin II receptor blocker (ARB)

 Medication Names:

  • losartan (Cozaar)
  • valsartan (Diovan)
  • irbesartan (Avapro)
  • candesartan (Atacand) 

Why this medication is prescribed: ARBs are used to decrease blood pressure in people with heart failure. ARBs decrease certain chemicals that narrow the blood vessels so blood can flow more easily through your body. They also decrease certain chemicals that cause salt and fluid build-up in the body.

ARBs, at the present time, are generally prescribed only when you can not tolerate an ACE inhibitor. Ongoing clinical trials will soon give further insight into the best prescription practices for ARBs in patients with heart failure.

When to take: ARBs can be taken on an empty or full stomach. Follow the label directions on how often to take this medication. The number of doses you take each day, the time allowed between doses and how long you need to take the medication will depend on the type of ARB inhibitor prescribed, as well as your condition. Note: it may take many weeks for you to feel the full effects of the medication.

Special directions: While taking this medication, have your blood pressure and kidney function checked regularly, as recommended by your doctor.

Food and drug interactions: There are no specific food or drug interactions with ARBs.

 Side effects and how to manage them 

  • Dizziness, lightheadedness, or faintness when you get out of bed or rise from a chair
    This side effect may be strongest after the first dose, especially if you have been taking a diuretic (water pill). Get up more slowly. Contact your doctor if these symptoms persist or are severe.
  •  Diarrhea, muscle cramps or weakness, back or leg pain, insomnia (difficulty sleeping), sinusitis or upper respiratory infection
    Contact your doctor if these symptoms are persistent or severe.
  • Irregular heartbeat, or fast or slow heartbeat
    Contact your doctor if these symptoms are persistent or severe.
  • Confusion
    Contact your doctor right away.
  • If you become sick with severe vomiting or diarrhea, you may become dehydrated, which can lead to low blood pressure. 
    Contact your doctor.
  • Also contact your doctor if you have any other symptoms that cause concern.

 Beta-blockers 

Medication Names:

  • bisoprolol (Zebeta)
  • carvedilol (Coreg)
  • metoprolol (Lopressor, Toprol-XL)

 Why this medication is prescribed: Beta-blockers improve the heart's ability to relax and decrease the production of harmful substances produced by the body in response to heart failure. Over time, beta-blockers improve the heart's pumping ability.

 Beta-blockers are essential for patients who have mild to moderate congestive heart failure. Whether or not beta blockers should be prescribed for patients with severe congestion and symptoms is still unclear. Beta-blockers are also used to control high blood pressure.

When to take: These medications should always be taken with meals or right away after meals. Food delays how fast beta-blockers are absorbed and should reduce side effects. Follow the label directions on how often to take this medication. The number of doses you take each day, the time allowed between doses and how long you need to take the medication will depend on your condition.

Special directions

  • Beta-blockers should not be used if you have severe lung congestion, extremely low blood pressure (hypotension) or slow pulse (bradycardia).
  • While taking this medication, your health care provider may tell you to take and record your pulse daily. He or she will tell you how rapid your pulse should be. If your pulse is slower than it should be, contact your doctor about taking your beta-blocker that day.
  • Never stop taking your medication, even if you feel that it is not working. When you start taking beta-blockers, your heart failure symptoms may become worse (for about 2 1/2 months) while your heart adjusts to the medication. Once your heart adjusts, you will feel better.
  • Long-term use of beta-blockers helps manage chronic heart failure and reduces the risk that your condition will worsen.

 Food and drug interactions: Beta-blockers are generally prescribed with diuretics, ACE inhibitors and digoxin. If you have more side effects after taking your medications together, contact your health care provider. You may need to change the times you are taking each medication.

 Side effects and how to manage them:

  • Dizziness or lightheadedness 
    This side effect may be strongest when you get out of bed or rise from a chair. Get up more slowly. Contact your doctor if these symptoms persist or are severe.
  • Tiredness, cold hands and feet, headache, nightmares, difficulty sleeping, nausea, heartburn, diarrhea or constipation, gas
    Contact your doctor if these symptoms are severe or persist.
  • Sudden weight gain
    Weight gain is common as your doctor increases your medication dose. Call your doctor if you gain 2 or more pounds in one day or if you continue to gain weight for more than 2 days.
  • Increased shortness of breath; wheezing; difficulty breathing; skin rash, slow, fast or irregular heartbeat; swelling of feet and lower legs; sudden weight gain; chest (heart) pain
    Contact your doctor right away.
  •  If you have severe vomiting or diarrhea, you may become dehydrated (lose too much water from the body), which can lead to low blood pressure. Contact your doctor.

Also contact your doctor if you have any other symptoms that cause concern.

Digoxin 

Medication names:

  • Digoxin (Lanoxin, Lanoxicaps)
  • Digitoxin (Crystodigin)

 Why this medication is prescribed: Digoxin helps an injured or weakened heart to work efficiently and to send blood through the body. It strengthens the force of the heart muscle's contractions, helps restore a normal, steady heart rhythm and improves blood circulation.

Digoxin is one of four primary medications used to treat the symptoms of heart failure. It may also be prescribed if you have atrial fibrillation (irregular heart beat rhythm).

 When to take: Digoxin is usually taken once a day. Try to take this medication at the same time every day. Follow the label directions on how often to take it. The time allowed between doses and how long you need to take it will depend on your condition. You may have to take this medication for a long time; possibly for the rest of your life.

Special directions 

  • While taking this medication, your health care provider may tell you to take and record your pulse daily. He or she will tell you how rapid your pulse should be. If your pulse is slower than recommended, contact your doctor about taking digoxin that day.
  • Keep all appointments with your doctor and the laboratory so your response to the drug can be monitored. You may have electro-cardiograms (EKGs) and blood tests, and your dose may be adjusted.
  • This medication may cause drowsiness. Do not drive a car or operate machinery until you know how this drug affects you.

Food and drug interactions 

  • Digoxin is generally prescribed in combination with diuretics, an ACE inhibitor and a beta-blocker. If you experience an increase in side effects after taking your medications together, contact your health care provider. You may need to change the times you are taking each medication.
  • If you are taking cholestyramine or colestipol, take it at least two hours after digoxin to prevent interactions.
  • Consult with your doctor before taking these over-the-counter medications, as they can interfere with the effects of digoxin: antacids; asthma remedies; cold, cough or sinus medicine; laxatives, medicines for diarrhea; or diet medications.
  • Follow your doctor's dietary advice, which may include:
    -- Following a low-sodium diet
    -- Taking a potassium supplement or including high-potassium foods (such as bananas and orange juice)

Side effects and how to manage them
Loss of appetite, nausea, and vomiting; changes in vision, such as flashes or flickering of light, sensitivity to light, seeing things larger or smaller than they are, blurring, color changes (yellow or green) and seeing halos or borders on objects; drowsiness, headache, confusion, depression, fatigue and muscle weakness; irregular heart beat or slow heart rate

Contact your doctor right away. Your dose may need to be changed. Once you and your doctor have determined the correct dose, you usually will not experience side effects if you take digoxin exactly as prescribed.

Also contact your doctor if you have any other symptoms that cause concern.

Diuretics

Medication names:

  • furosemide (Lasix)
  • bumetanide (Bumex)
  • torsemide (Demadex)
  • hydrochlorothiazide (HydroDIURIL)
  • metolazone (Zaroxolyn)

 Categories of diuretics: Diuretics are categorized as thiazide-like (metolazone and hydrochlorothiazide) and loop diuretics (furosemide, bumetanide).

 Why this medication is prescribed: Diuretics, also commonly known as "water pills" cause the kidneys to get rid of unneeded water and salt from the tissues and bloodstream into the urine. Getting rid of excess fluid makes it easier for your heart to pump. It is used to treat high blood pressure and reduce the swelling and water build-up caused by various medical problems, including heart failure. It also helps make breathing easier.

 When to take: Follow the label directions on how often to take this medication. If you are taking a single dose a day, take it in the morning with your breakfast or right away after eating your breakfast. If you are taking more than one dose a day, take the last dose no later than 4 p.m.

 The number of doses you take each day, the time allowed between doses and how long you need to take the medication will depend on the type of diuretic prescribed, as well as your condition.

Special directions 

  • Weigh yourself at the same time every day (on the same scale) and record your weight. Call your doctor if you gain 2 pounds in one day or 5 pounds in one week.
  • While taking this medication, have your blood pressure and kidney function tested regularly, as advised by your doctor.
  • Keep all appointments with your doctor and the laboratory so that your response to this medication can be monitored.

 Food and drug interactions 

  • Diuretics are generally prescribed in combination with an ACE inhibitor, digoxin, and a beta-blocker. If you experience an increase in side effects after taking your medications together, contact your health care provider. You may need to change the times you are taking each medication.
  • Potassium-sparing diuretics increase the effects of digoxin and lithium. They may increase your body's potassium level if taken with ACE inhibitors.
  • Before this medication is prescribed, tell your health provider if you are taking: other medications for high blood pressure, digoxin, indomethecin, lithium, probenecid or corticosteroids (prednisone).
  • Before this medication is prescribed, tell your health care provider if you have diabetes, kidney disease, liver disease or gout.
  • Follow your doctor's dietary advice, which may include:
    -- Following a low-sodium diet
    -- Taking a potassium supplement or including high-potassium foods (such as bananas and orange juice). Note: some types of diuretics cause your body to lose potassium.
    -- If you are taking a "potassium-sparing" diuretic (triamterene or spirnolactone), your doctor may want you to avoid potassium-rich foods, salt substitutes, low-sodium milk and other dietary sources of potassium.
  • Alcohol and sleep aids may increase the side effects of this medication and should be avoided.

Side effects and how to manage them: 

  • Frequent urination
    This may last for up to six hours after a dose.
  • Extreme tiredness or weakness
    These effects should decrease as your body adjusts to the medication. Call your doctor if these symptoms persist.
  • Muscle cramps or weakness, thirst
    Be sure that you are taking your potassium supplement correctly, if prescribed. Contact your doctor if these symptoms persist.
  • Dizziness, lightheadedness
    Try rising more slowly when getting up from a lying or sitting position.
  • Blurred vision, confusion, headache, increased perspiration (sweating), restlessness
    If these effects persist or are severe, contact your doctor.
  • Dehydration -- signs include dizziness, extreme thirst, excessive dryness of the mouth, decreased urine output, dark-colored urine or constipation.
    If these symptoms occur, don't assume you need more fluids. Call your doctor if these symptoms occur.
  • Fever, sore throat, cough, ringing in the ears, unusual bleeding or bruising, rapid and excessive weight loss
    Contact your doctor right away.
  • Skin rash
    Stop taking the medication and contact your doctor right away.
  • Loss of appetite, nausea, vomiting or muscle cramps
    Be sure that you are taking your potassium supplement correctly, if prescribed.

Contact your doctor if you have any other symptoms that cause concern.

 Vasodilators/Nitrates 

Medication names:

  • isosorbide dinitrate (Dilatrate-SR, Iso-Bid, Isonate, Isorbid, Isordil, Isotrate, Sorbitrate)
  • isorbide mononitrate (IMDUR)
  • hydralazine (Apresoline)

Why this medication is prescribed: Vasodilators are used to treat heart failure and control high blood pressure by relaxing the blood vessels so blood can flow more easily through the body. Vasodilators are prescribed for patients who are can not take ACE inhibitors.

 When to take: Follow the label directions on how often to take this medication. Take this medication at evenly spaced times, with meals, while you are awake.

 The number of doses you take each day, the time allowed between doses and how long you need to take the medication will depend on your condition.

Special directions

  • While taking this medication, have your blood pressure checked regularly, as advised by your doctor.
  • Keep all appointments with your doctor and the laboratory so that your response to the drug can be monitored.
  • This medication may cause dizziness. Do not drive a car or operate dangerous machinery until you know how this drug affects you.

 Side effects and how to manage them: 

  • Headache; rapid, irregular or pounding heartbeat; numbness or tingling of the fingers or toes; loss of appetite and diarrhea
    Your doctor will probably prescribe additional medication to control these side effects. If they persist, contact your doctor.
  • Upset stomach, flushing of face or neck
    Contact your doctor if these side effects are persistent or severe.
  • Fever, joint or chest pain, sore throat, skin rash (especially on the face), unusual bleeding or bruising, weight gain, swelling of the ankles.
    Contact your doctor right away.

Potassium or Magnesium 

Medication names:

  • Potassium: Kaochlor 10%, Kaon CL, Kay Ciel, K-Lor, Klotrix, K-Lyte, Slow-K, K-Dur and others
  • Magnesium oxide: (Mag-Ox, Uro-Mag)

Why this medication is prescribed: Potassium and magnesium replace potassium which can be lost because of increased urination when taking diuretics.

When to take: Take this medication right after meals or with food. Follow the label directions on how often to take it. The number of doses you take each day, the time allowed between doses and how long you need to take it will depend on the type of medication prescribed, as well as your condition.

Special directions

  • While taking this medication, have your blood pressure checked regularly, as advised by your doctor.
  • Keep all appointments with your doctor and the laboratory so that your response to the drug can be monitored.

Food and drug interactions

  • If you are using a salt substitute, tell your doctor. Many salt substitutes contain potassium. Follow your doctor's dietary guidelines for including potassium foods in your diet.
  • Your doctor will consider the other heart failure medications you are taking, such as ACE inhibitors or certain diuretics, when determining your potassium dosage.

Side effects and how to manage them

  • Nausea, vomiting, diarrhea, abdominal discomfort
    Take the medication with or right after meals with a full glass of water or fruit juice. If these side effects continue, contact your doctor.
  • If you take controlled-release tablets or capsules and experience severe vomiting (especially blood) and abdominal pain or swelling, 
    stop taking the medication and contact your doctor right away.
  • Black, tarry or bloody stools (signs of stomach bleeding)
    Contact your doctor right away.
  • (Rare) Confusion; irregular or slow heartbeat; numbness or tingling in hands, feet, or lips; shortness of breath or difficult breathing; unexplained anxiety; unusual tiredness or weakness
    Contact your doctor right away.

Aldosterone inhibitor

Medication names

  • spirnolactone (Aldactone)

Why this medication is prescribed: Spirnolactone is a potassium-sparing diuretic. It used to be prescribed to reduce the swelling and water build-up caused by heart failure. Diuretics cause the kidneys to get rid of unneeded water and salt from the tissues and blood into the urine.

In the past few years, spirnolactone has been prescribed in low doses to prevent heart failure symptoms from becoming worse. Spirnolactone protects the heart by blocking a certain chemical (aldosterone) in the body that causes salt and fluid build-up. This medication is used to treat patients with severe heart failure when systolic dysfunction is present.

When receiving spirnolactone, you will be given a low dose that does not provide enough diuretic effects by itself. Your doctor will prescribe a loop or thiazide-like diuretic in addition to spirnolactone.

When to take: Follow the label directions on how often to take this medication. If you are taking a single dose a day, take it in the morning with your breakfast or right after eating your breakfast. If you are taking more than one dose a day, take the last dose no later than 4 p.m.

The number of doses you take each day, the time allowed between doses and how long you need to take the medication will depend on your condition.

Special directions

  • Weigh yourself at the same time every day (on the same scale) and record your weight. Call your doctor if you gain 2 pounds in one day or 5 pounds in one week.
  • While taking this medication, have your blood pressure and kidney function tested regularly, as advised by your doctor.
  • Keep all appointments with your doctor and the laboratory so that your response to this medication can be monitored.

Foods and drug interactions

  • Spirnolactone is generally prescribed in combination with an ACE inhibitor, digoxin, other diuretic and beta-blocker. If you experience an increase in side effects after taking your medications together, contact your health care provider. You may need to change the times you are taking each medication.
  • Before this medication is prescribed, tell your health provider if you are taking: other medications for high blood pressure, cyclosporine, potassium-containing medications, digoxin or lithium.
  • Before this medication is prescribed, tell your health care provider if you have diabetes, kidney disease, liver disease, gout, a history of kidney stones, menstrual problems or breast enlargement.
  • Follow your doctor's dietary advice, which may include:
    -- Following a low-sodium diet
    -- Taking a potassium supplement or including high-potassium foods (such as bananas and orange juice)

Side effects and how to manage them 

  • Extreme tiredness
    This side effect may be strongest when you first start taking the medication. It should decrease as your body adjusts to the medication. Call your doctor if this symptom persists.
  • Increased urination
    This is normal and may last for up to 6 hours after a dose.
  • Abnormal enlargement of one or both breasts in men. May be associated with breast pain.
    This is a temporary side effect. Contact your doctor if this symptom persists or is severe.
  • Upset stomach
    Take this medication with meals or milk to reduce this symptom. Contact your doctor if this symptom persists or is severe.
  • Skin rash or itching
    Stop taking the medication and call your doctor right away.
  • Shortness of breath
    Call your doctor right away.
  • Confusion; irregular heartbeat; nervousness; numbness or tingling in the hands, feet or lips
    Contact your doctor right away.

Calcium channel blockers

Medication names:

  • amlodipine (Norvasc)
  • felodipine (Plendil)

Why this medication is prescribed: Calcium channel blockers are prescribed to treat angina (chest pain) and high blood pressure. Calcium channel blockers affect the movement of calcium in the cells of the heart and blood vessels. As a result, calcium channel blockers relax blood vessels and increase the supply of blood and oxygen to the heart, while reducing its workload.

Calcium channel blockers are only used to treat heart failure caused by high blood pressure when other medications to lower blood pressure are ineffective. Calcium channel blockers should NOT be used if you have heart failure due to systolic dysfunction.

When to take: Take this medication with food or milk. Follow the label directions on how often to take it. The number of doses you take each day, the time allowed between doses and how long you need to take it will depend on the type of medication prescribed and on your condition.

Special directions

  • While taking this medication, have your blood pressure checked regularly, as advised by your doctor.
  • Keep all appointments with your doctor and the laboratory so that your response to the drug can be monitored.
  • While taking this medication, your health care provider may tell you to take and record your pulse daily. Your provider will tell you how rapid your pulse should be. If your pulse is slower than advised, contact your doctor about taking your channel blocker that day.

Food and drug interactions

  • Do not eat grapefruit or drink grapefruit juice while taking a calcium channel blocker.
  • Alcohol interferes with the effects of calcium channel blockers and increases the side effects -- it should be avoided while taking this medication.

Side effects and how to manage them

  • Drowsiness, increased appetite
    Contact your doctor if these side effects are persistent or severe
  • Weight gain, breathing difficulty, coughing or wheezing, irregular or slow heartbeat, skin rash
    Contact your doctor right away.

Inotropic therapy

Medication names:

  • dobutamine (Dobutrex)
  • milrinone (Primacor)

Why this medication is prescribed: Inotropic therapy is used to stimulate an injured or weakened heart to pump harder to send blood through the body. They help the force of the heart muscle's contractions and relax constricted blood vessels so blood can flow more smoothly. Inotropic therapy may also speed up the heart's rhythm.

Inotropic therapy is used in end-stage heart failure to help relieve and control heart failure symptoms so that you are better able to perform your daily activities. These medications are only used when other medications no longer control heart failure symptoms.

When to take: Inotropic therapy is first administered in the hospital where you can be closely monitored.

Dobutamine and milrinone are intravenous medications that will be administered by an infusion pump to help ensure the dose is accurate. These medications may be ordered by your doctor to be given continuously or periodically over 6 to 72 hours, one or more times per week.

Special directions

  • Even if you feel well, do not discontinue your inotropic therapy medication from your intravenous catheter line or from your infusion pump without consulting your doctor. If you take one of these medications after being discharged from the hospital, a home health nurse will provide specific directions on how to care for your intravenous site, catheter and infusion pump. Do not skip doses or take less or more of the medication than your doctor prescribed.
  • Keep all appointments with your doctor and the laboratory so your response to this medication can be monitored.
  • While taking this medication, your health care provider will tell you to take and record your pulse daily. Your provider will tell you how rapid your pulse should be. If your pulse is higher than advised, contact your doctor.
  • While taking this medication, your health care provider will also tell you to take and record your blood pressure daily. Your provider will tell you what your blood pressure range should be. If your blood pressure is lower than advised, contact
    your doctor.
  •  Be sure that you always have enough infusion bags of your medication. Check your supply before vacations, holidays or other occasions when you may be unable to obtain it.
  •  Never administer other intravenous medications through the same intravenous line.
  • Take precaution to prevent infection while you are taking this medication. Your health care provider will give you information on how to prevent infection.

Food and drug interactions

  •  Carefully follow the low-sodium (low-salt) diet and daily exercise program advised by your doctor.
  •  Alcohol increases the side effects of this medication and should be avoided.

Side effects and how to manage them
Notify your doctor or nurse right away the first time any of these side effects occur:

  • Headache
  • Increased heart rate
  • High blood pressure
  • Nausea
  • Vomiting
  • Shortness of breath
  • Faintness, dizziness or lightheadedness
  • Mild leg cramps or tingling sensation

Contact your doctor if these symptoms are persistent or severe.

 If any of these side effects occur, STOP THE INFUSION and contact your doctor right away:

  • Irregular, fast heartbeat (more than 120 beats per minute)
  • Pain or swelling at infusion site
  • Fever of 101°F (38.3°C) or higher.
  • Pump malfunction. (Then call the pharmacy immediately for a replacement).

© Copyright 1995-2005 The Cleveland Clinic Foundation.

This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition. For additional written health information, please contact the Health Information Center at the Cleveland Clinic (216) 444-3771 or toll-free (800) 223-2273 extension 43771 or visit www.clevelandclinic.org/health/.

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