The principal setting is shown in the picture. A generator establishes the high frequency power, which is then passing through a special needle into the tumor. A grounding pad closes the electric circle.

The current causes the ions (charged atoms in tissues) to vibrate at very high speeds. The ions move back and forth so rapidly that they create friction, which produces heat. Heat is a very effective means of killing tissue. As tissue temperature rises above 45 °C (113^° F), protein is permanently damaged and cell membranes fuse.