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Director: David Huang, M.D., Ph.D.
Location: Lerner Research Institute (LRI), ND2-96, Cleveland Clinic Foundation
Phone: 216/445-1531
Cole Eye Institute
9500 Euclid Avenue, i32
Cleveland, Ohio 44195
Office telephone: 216/444-0848
Fax: 216/445-8475
Email: huangd@ccf.org
Sung Jeon, M.S., Lerner Research Institute/Case Western Reserve University graduate student; Mark Shure, Ph.D., project scientist; Yan Li, M.S., Lerner Research Institute/Case Western Reserve University graduate student; Raj Shekhar, Ph.D., Lerner Research Institute Biomedical Engineering project staff (consultant to the group); Ou (Tomy) Tan, Ph.D., research associate; Roger Lin, M.S., Lerner Research Institute/Case Western Reserve University graduate student; and David Huang, M.D., Ph.D., laboratory director.
Not pictured:
Maolong Tang, M.S., Ohio State Universitygraduate student, and Kimberly Powell, Ph.D., Lerner Research Institute Biomedical Engineering project staff (consultant to the group).
Scientific goals of the Huang Lab:
Dr. David Huang pioneered the biomedical application of optical coherence domain reflectometry (OCDR) and optical coherence tomography (OCT). The primary goal of his laboratory has been to advance the clinical applications of OCT. This work has included the development of OCT prototypes with improved capabilities and novel principles, new image processing and segmentation software and applications to new clinical areas.
Current research projects:
Partnership for Research in Optical Coherence Tomography
This Biomedical Research Partnership with researchers at Duke University aims to advance the state of the art in diagnostic anatomical and functional imaging in situ at the micron scale, by developing fundamental advances in the technology of OCT. The Cleveland Clinic research group concentrates on the corneal and retinal applications of OCT.
Advanced Imaging for Glaucoma
This Biomedical Research Partnership aims to improve the diagnosis and monitoring of glaucoma using a combination of imaging modalities: advanced OCT, laser scanning polarimetry and scanning laser tomography. The value of advanced imaging in predicting glaucomatous change will be assessed in a multi-center prospective trial of glaucoma, ocular hypertensive and normal subjects. Advanced OCT technologies will be developed for clinical use.
Optical Coherence Domain Reflectometry in Brain Probes
The major goal of this project is to improve the safety, speed and accuracy of brain probe implantation using OCDR as a guidance mechanism. Deep brain stimulation via implanted microelectrodes is important for the treatment of Parkinson disease, essential tremor and other neurological conditions. This pilot project in collaboration with members of the CCF Department of Neurosurgery will develop an integrated OCDR/electrode brain probe and test the differentiation of brain tissues in an animal model.
Corneal and Anterior Segment Optical Coherence Tomography
This research aims to develop high-speed OCT for corneal topography, pachymetric mapping, and anterior segment imaging applications using a Zeiss anterior segment scanner (AC-OCT) prototype. Scan patterns and image processing software will be developed. The project includes clinical trials for LASIK, narrow angle glaucoma, and other anterior segment pathologies and surgeries.
How to contact us:
Huang, David: huangd@ccf.org
Jeon, Sung: sung.jeon@cwru.edu
Li, Yan: yxl69@cwru.edu
Lin, Roger: rogerlin@cwru.edu
Powell, Kimberly: powellk@ccf.org
Shekhar, Raj: shekhar@ccf.org
Shure, Mark: shurem@ccf.org
Tan, Ou: tano@ccf.org
Tang, Maolong: tang93@osu.edu
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