Orange High School

Pepper Pike, OH

Instructor

Maureen Cavotta

Science Intern

David Litt

Research Project

Clinical Significance of Non-Diagnostic Molecular Changes in Urine Detected by UroVysion Fluorescence in situ Hybridization (FISH) in Patients under Surveillance for Bladder Cancer

Click on the research project title above to learn about the science that inspired the artwork to the right.

Bladder Cancer with FISH TestingClick to View Larger Image

Bladder Cancer with FISH Testing

Maria Rigden

eXpressions™ Award: Blue Ribbon

My piece for the Cleveland Clinic was based on FISH testing in bladder cancer patients. Fluorescence in situ Hybridization (FISH) testing uses red, green and aqua fluorescent dyes to detect chromosomal changes in a cell that indicates whether or not the cell is cancerous. The peach colored background of my piece represents the normal bladder tissue and the purple areas represent the spread of cancer throughout the once healthy tissue. The copper wire is supposed to represent the actual tumor growing in stalks over the cancerous tissue. The green, red and aqua glass beads on the copper wire are the results of FISH testing on the tissue, the large amount of red, green and aqua lights show that the tissue is cancerous.

Bladder-CancerClick to View Larger Image

Bladder-Cancer

Anastasia Davydovskaya

eXpressions™ Award: Honorable Mention

For my painting, I chose to depict an old man getting flushed down the toilet while hooked onto the pole of a fish. I did this for many reasons. First, the group most prone to bladder cancer is elderly males. The fish has hooked the old man on the fishing pole, which symbolizes the elderly man testing positive for bladder cancer. Getting flushed down the toilet simply means that his life is in jeopardy. The fishing pole is three different colors: red, aqua, and green, which are the only colors of the cells present in the bladder when one has bladder cancer. I chose to depict such a grave subject in a more lighthearted way to show that cancer does not always mean it is the end.

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