Randi Michel
Pilot Study to Identify Women at High Risk for Hereditary Breast Cancer in a Community Mammography Clinic Population

SchoolHawken High School


ProgramScience


MentorJill Polk


DepartmentHillcrest Hospital Cancer Center


Research
Pilot Study to Identify Women at High Risk for Hereditary Breast Cancer in a Community Mammography Clinic Population
Hypothesis
Data from previous studies indicate that about 10% of women will likely be at high risk of hereditary breast and ovarian cancer (HBOC) syndrome. The mammography population should be the appropriate location for HBOC risk screening.
Methodology
The Pedigree Assessment Tool (PAT) was distributed in a community mammography clinic population to ascertain the percentage of patients who are at high risk for HBOC and thus appropriate for genetic counseling and genetic risk assessment. Risk was determined using the validated PAT point scoring system. Postmenopausal breast cancer was allocated three points; early-onset breast cancer, four points; ovarian cancer, five points; male breast cancer, eight points; and Ashkenazi Jewish heritage, four points.
Outcomes
Using the validated PAT scoring system, 12.3% of total mammography patients were found to be at a high HBOC risk, 11.9% were at moderately increased risk, 28.5% were at low risk and 47.4% had no family history of breast or ovarian cancer. The incidence of high risk patients is slightly higher than predicted. This supports that implementing a risk screening and genetic counseling referral system with PAT in the mammography population would be sensible and effective.

Interpretations

Inheritance by Ozan Cubukcu

Biology by Margo Uhrman

Una oda a la ciencia/An Ode to Science by Margret Erlendsdottir

Self-Examination by Ali Foti

Optimism in DNA by Grace Kelemen

Family Tree by Jianna Lobur

Full Bloom by Allie French

Julie Kuilder, Alyssa Licker, Andrea Panzuto

Heredity Breast and Ovarian Cancer Risk, Graphing Optimism in DNA, Number of Syllables in "An Ode to Science"