The Cleveland Clinic Lerner College of Medicine is transforming medical education through its unique, five-year curriculum focused on active learning methods including problem-based learning, labs, seminars and electronically based self-study programs. This approach fosters critical thinking, self-directed learning, and individual knowledge – the skills that will ensure their future success as physician investigators. The program is based on nine competencies, six of which match ACGME (Accreditation Council for Graduate Medical Education) competencies.