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DNA DAMAGE IN MALE INFERTILITY

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1.    PDF File (agradoc106.pdf 266 Kb)
Alvarez, J.G., Sharma, R.K., Ollero, M., Saleh, R.A., Lopez, M.C., Thomas A.J.,Jr., Evenson, D.P., and Agarwal, A. (2002):
Increased DNA damage in sperm from leukocytospermic semen samples as determined by the sperm chromatin structure assay (SCSA).
Fertil Steril, 78(2): 319-329.
 

2.    PDF File (agradoc107.pdf 88 Kb)
Saleh, R.A., Agarwal, A., Nelson, D.R., Nada, E.A., El-Tonsy, M.H., Alvarez, J.G., Thomas, A.J., Jr., and Sharma, R.K. (2002):
Increased damage of sperm nuclear DNA in normozoospermic infertile men: a prospective study.
Fertil Steril, 78(2): 313-318.
 

3.    PDF File (agradoc118.pdf 127 Kb)
Saleh R.A., Agarwal A., Nada E.A., El-Tonsy M.H., Sharma R.K., Meyer A., Nelson, D.R., Thomas A.J. Jr. (2003):
Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility.
Fertil Steril 79: 1597-1605.
 

4.    PDF File (agradoc121.pdf 183 Kb)
Agarwal, A and Said, TM (2003):
Role of sperm chromatin abnormalities and DNA damage in male infertility. Review Article.
Hum Reprod Update 9: 331-345.
 

5.    PDF File (agradoc123.pdf 119 Kb)
Wang, X, Sharma, RK, Sikka, SC, Thomas, AJ, Jr, Falcone, T, and Agarwal, A. (2003):
Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male-factor infertility.
Fertil Steril 80: 531-535.
 

6.    PDF File (agradoc129.pdf 64 Kb)
Saleh, R.A., Agarwal, A., Sharma, R.K., Said, T.M., Sikka, S.C., Thomas, A.J., Jr. (2003):
Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele.
Fertil Steril 80: 1431-1436.
 

7.    PDF File (agradoc131.pdf 167 Kb)
Moustafa, MH, Sharma, RK, Thornton, J, Mascha, E, Abdel-Hafez, MA, Thomas, AJ, Jr., and Agarwal, A (2004):
Relationship between ROS production, apoptosis and DNA denaturation in spermatozoa from patients examined for infertility.
Hum Reprod 19: 129-138.
 

8.      PDF File (agrach016.pdf   2497 kb)
Agarwal, A. and Said, T.M. (2004):
Sperm chromatin assessment.
In: Textbook of ART, 2nd Edition, (Editors: D.K. Gardner, A. Weissman, C.M. Howles, and Z. Shoham), Taylor & Francis Group, plc, London, UK, Chapter 7, pp. 93-106.
 

9.    PDF File (agradoc145.pdf 281 Kb)
Sharma, RK, Said, TM, Agarwal, A (2004):
Sperm DNA damage and its clinical relevance in assessing reproductive outcome. Review Article.
Asian J Androl 6: 139-148.
 

10.    PDF File (agradoc148.pdf 81 Kb)
Agarwal, A and Allamaneni, SSR (2004):
The effect of sperm DNA damage on assisted reproduction outcome: a review. Review Article.
Minerva Ginecol 56: 235-245.
 

11.    PDF File (agradoc161.pdf 78 Kb)
Agarwal, A and Allamaneni, SSR (2004):
Significance of human sperm chromatin damage in assisted reproduction.
ART & Science 4: 2-4.
 

12.    PDF File (agradoc163.pdf 164 Kb)
Said, TM, Agarwal, A, Sharma, RK, Thomas, AJ, Jr, Sikka, SC (2005):
Impact of sperm morphology on DNA damage caused by oxidative stress induced by ß-nicotinamide adenine dinucleotide phosphate.
Fertil Steril 83: 95-103.
 

13.    PDF File (agradoc164.pdf 122 Kb)
Agarwal, A, and Said, TM (2005):
Oxidative stress, DNA damage and apoptosis in male infertility - a clinical approach. Review Article.
BJU International 95: 503-507. (PubMed)
 

14.    PDF File (agradoc181.pdf 85 Kb)
Said, TM, Aziz, N, Sharma, RK, Lewis-Jones, I, Thomas, AJ, Jr, and Agarwal, A (2005):
Novel association between sperm deformity index and oxidative stress-induced DNA damage in infertile male patients.
Asian J Androl 7: 121-126.
 

15.    PDF File (agradoc185.pdf 81 Kb)
Agarwal, A, and Allamaneni, SS (2005):
Sperm chromatin damage in etiopathogenesis of male infertility. Review Article.
Revista Internacional de Andrologia 3: 31-37.
 

16.    PDF File (agradoc188.pdf 72 Kb)
Agarwal, A and Allamaneni, SS (2005):
Sperm DNA damage assessment: a test whose time has come. Review Article.
Fertil Steril 84: 850-853.
 

17.    PDF File (agradoc259.pdf 178 Kb)
Coccuzza, M, Sikka, S, Athayde, K, Agarwal, A. (2007):
Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: An evidence based analysis. Review Article.
Int Braz J Urol. 33(5): 603-621.
 

18.    PDF File (agradoc317.pdf 83 Kb)
Fernández, J. L.,Vélez de la Calle, J F, Dioleyda Cajigal, M. T., Agarwal, A, Gosálvez, J. (2009):
Sperm DNA integrity and male infertility: current perspectives. Review Article.
Arch of Med Sci. 5, 1A: S55-S62.
 

19.    PDF File (agradoc327.pdf 221 Kb)
Varghese A, Bragais F, Mukhopadhyay D, Kundu S, Pal M, Bhattacharyya A, Agarwal A (2009):
Human sperm DNA integrity in normal and abnormal semen samples and its correlation with sperm charachteristics.
Andrologia 41(4): 207-215.
 

20.    PDF File (agradoc334.pdf 113 Kb)
Grunewald S, Reinhardt M, Blumenauer V, Said T, Agarwal A, Hmeidan F, Glander H, Paasch U (2009):
Increased sperm chromatin decondensation in selected nonapoptotic spermatozoa of patients with male infertility.
Fertil Steril 92(2): 572-577. Epub 2008 Sep 27.
 

21.    PDF File (agradoc345.pdf 570 Kb)
Jha, R., Agarwal, A, Mahfouz, R, Paasch, U, Grunewald, S, Sabanegh, E, Yadav. S, Sharma, R. (2009):
Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation.
Fertil Steril 91(3): 782-790. Epub 2008 Mar 12.
 

22.    PDF File (agradoc346.pdf 508 Kb)
Mahfouz, R, Sharma, R, Kerstin P, Jha, R, Paasch, U, Grunewald, S, Agarwal, A (2009):
Evaluation of poly (ADP- ribose) polymerase cleavage (cleaved-PARP) in ejaculated human sperm fractions after induction of apoptosis.
Fertil Steril 91(5): 2210-2220. Epub 2008 May 23.
 

23.    PDF File (agradoc353.pdf 2063 Kb)
Agarwal A, Mahfouz RZ, Sharma RK, Sarkar O, Mangrola D, Mathur PP (2009):
Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes. Review Article.
Reprod Biol Endocrinol 2009 Dec 5: 7:143.
 

24.    PDF File (agradoc357.pdf 451 Kb)   new
Mahfouz R, Sharma R, Thiyagarajan A, Kale V, Gupta S, Sabanegh E, Agarwal A (2010):
Semen characteristics and sperm DNA fragmentation in infertile men with low and high levels of seminal reactive oxygen species.
Fertil Steril 94: 2141-2146.
 

25.    PDF File (agradoc411.pdf 1761 Kb)   new
Singh A and Agarwal A (2011):
The Role of Sperm Chromatin Integrity and DNA Damage on Male Infertility.
The Open Reproductive Science Journal, Special Issue on Advances in Andrology and Male Reproductive Health, Guest Editors: Sandro C. Esteves and Ashok Agarwal, Vol. 3: 65-71.
 

26.
Sharma,R, Sabanegh,E, Mahfouz,R, Gupta,S, Thiyagarajan,A, Agarwal,A (2010):
TUNEL as a test for sperm DNA damage in the evaluation of male infertility.
Urology. (In press)
 

27.    PDF File (agradoc429.pdf 438 Kb)   new
Dada R, Kumar M, Jesudasan R, Fernández J, Gosálvez J, Agarwal A (2012):
Epigenetics and its role in male infertility. Review Article.
J Assist Reprod Genet. 29(3):213-223.
 

 
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