Over the last decade we have defined the role of oxidative stress and its implications in female reproduction and reproductive diseases. We have been innovative in increasing our understanding of the nature of oxidative stress, its causes and the factors that influence it, as well as the role of antioxidants and their effects on infertility, fertilization, pregnancy and other pregnancy-associated diseases such as preeclampsia etc. Oxidative stress is one of the main underlying mechanisms in the pathogenesis of a continuum of disease processes such as spontaneous abortion, hydatidiform mole, and preeclampsia. Recurrent pregnancy loss may be caused by oxidative damage. Oxidative stress and damage induced by reactive oxygen species may be the missing pieces of the puzzle in abortion and recurrent pregnancy loss of unexplained etiology. We have provided excellent review articles and book chapters to illustrate the importance of oxidative stress in female reproductive diseases.